Lewis Acid Catalyzed Formal (3+2)-Cycloaddition of Bicyclo[1.1.0]butanes with Ketenes,Angewandte Chemie International Edition

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Lewis Acid Catalyzed Formal (3+2)-Cycloaddition of Bicyclo[1.1.0]butanes with Ketenes
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-05-11 , DOI: 10.1002/anie.202304771
Niklas Radhoff ₁ , Constantin G Daniliuc ₁ , Armido Studer ₁

Affiliation

A mild, efficient and transition-metal-free method for the preparation of valuable bicyclo[2.1.1]hexanes by Lewis acid catalyzed formal (3+2)-cycloaddition of readily available bicyclo[1.1.0]butanes and ketenes is presented. Excellent tolerance towards functional groups and versatile substitution patterns in the 3-position of the bicyclo[2.1.1]hexane core are demonstrated.

中文翻译：

路易斯酸催化双环[1.1.0]丁烷与乙烯酮的缩甲醛(3+2)-环加成反应

提出了一种温和、高效且无过渡金属的方法，通过路易斯酸催化容易获得的双环[1.1.0]丁烷和乙烯酮的形式(3+2)-环加成来制备有价值的双环[2.1.1]己烷。双环[2.1.1]己烷核心3位上的官能团具有优异的耐受性和多种取代模式。

更新日期：2023-05-11

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