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Current Advances in Immunomodulatory Biomaterials for Cell Therapy and Tissue Engineering
Advanced Therapeutics ( IF 3.7 ) Pub Date : 2023-05-10 , DOI: 10.1002/adtp.202300002
Boram Kim 1 , Lipi Pradhan 2 , Andrea Hernandez 3 , Devyani Yenurkar 2 , Susheel Kumar Nethi 4 , Sudip Mukherjee 2
Affiliation  

Biomaterials have gained immense attention for various diseases due to their unique advantages over chemical drugs regarding cost, ease of production, toxicity, and therapeutic efficacy. However, these materials need an inert delivery system that locally delivers cells and minimally elicits foreign body response (FBR). In this aspect, various immunomodulatory biomaterials, including silk, collagen, fibrin, hyaluronic acid, and alginate-based biomaterials, have great potential due to large natural sources, ease of extraction, low cost, chemical inertness, facile surface functionalization, long-term polymeric stability, high biocompatibility, and fine tunability of biomaterials sizes and shapes. In this review article, the recent advancements in the biomedical applications of immunomodulatory biomaterials in different diseases, including diabetes, cancer, cardiovascular disease, bone regeneration, etc, are highlighted. Moreover, the FBR on immunomodulatory biomaterials is discussed and the current and future strategies for the potential mitigation of considerable immune responses toward immunomodulatory biomaterials and devices are highlighted.

中文翻译:

用于细胞治疗和组织工程的免疫调节生物材料的最新进展

生物材料由于其在成本、易于生产、毒性和治疗效果等方面比化学药物具有独特的优势,在各种疾病方面受到了极大的关注。然而,这些材料需要惰性输送系统来局部输送细胞并最小化引起异物反应(FBR)。在这方面,各种免疫调节生物材料,包括丝、胶原蛋白、纤维蛋白、透明质酸和藻酸盐基生物材料,由于天然来源丰富、易于提取、成本低廉、化学惰性、易于表面功能化、长期使用等优点,具有巨大的潜力。聚合物稳定性、高生物相容性以及生物材料尺寸和形状的精细可调性。在这篇综述文章中,免疫调节生物材料在不同疾病(包括糖尿病)中的生物医学应用的最新进展,癌症、心血管疾病、骨再生等受到关注。此外,还讨论了免疫调节生物材料上的 FBR,并强调了当前和未来潜在缓解对免疫调节生物材料和设备的大量免疫反应的策略。
更新日期:2023-05-10
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