“Trojan Horse” Phototheranostics: Fine-Engineering NIR-II AIEgen Camouflaged by Cancer Cell Membrane for Homologous-Targeting Multimodal Imaging-Guided Phototherapy,Advanced Materials

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“Trojan Horse” Phototheranostics: Fine-Engineering NIR-II AIEgen Camouflaged by Cancer Cell Membrane for Homologous-Targeting Multimodal Imaging-Guided Phototherapy
Advanced Materials ( IF 27.4 ) Pub Date : 2023-05-09 , DOI: 10.1002/adma.202302639
Jie Cui _{1,

2} , Fei Zhang _{1,

2} , Dingyuan Yan ₁ , Ting Han ₁ , Lei Wang ₁ , Dong Wang ₁ , Ben Zhong Tang ₃

Affiliation

Multimodal phototheranostics on the basis of a single molecule with one-for-all characteristics represents a convenient approach for effective cancer treatment. In this report, a versatile molecule featured by aggregation-induced emission, namely DHTDP, synchronously enabling second near-infrared (NIR-II) fluorescence emission and efficient photothermal conversion is developed by elaborate structural modulation. By camouflaging DHTDP nanoparticles with cancer cell membrane, the resultant biomimetic nanoparticles exhibit significantly both facilitated delivery efficiency and homologous targeting capability, and afford precise imaging guidance and maximize therapeutic outcomes in form of NIR-II fluorescence imaging (FLI)–photoacoustic imaging (PAI)–photothermal imaging (PTI) trimodal imaging-guided photothermal therapy (PTT). This study presents the first example of biomimetic multimodal phototheranostics loaded by homogeneity-targeting cell membrane, thus brings a new insight into the exploration of superior phototheranostics for practical cancer theranostics.

中文翻译：

“特洛伊木马”光治疗学：通过癌细胞膜伪装的精细工程 NIR-II AIEgen，用于同源靶向多模态成像引导光疗

基于具有一一对应特性的单分子的多模式光治疗代表了一种有效癌症治疗的便捷方法。在本报告中，通过精细的结构调制开发了一种具有聚集诱导发射特征的多功能分子，即DHTDP，可同步实现第二近红外（NIR-II）荧光发射和高效的光热转换。通过用癌细胞膜伪装 DHTDP 纳米颗粒，所得仿生纳米颗粒显着提高了递送效率和同源靶向能力，并以 NIR-II 荧光成像 (FLI)-光声成像 (PAI) 的形式提供精确的成像指导并最大化治疗结果–光热成像（PTI）三模态成像引导光热治疗（PTT）。这项研究提出了第一个由同质靶向细胞膜加载的仿生多模式光治疗学的例子，从而为探索实用癌症治疗学的优越光治疗学带来了新的见解。

更新日期：2023-05-09

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