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Orchestrated Strategies for Developing Fluorophores for NIR-II Imaging
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2023-05-10 , DOI: 10.1002/adhm.202300537
Xin Feng 1 , Long Wei 1 , Yanlin Liu 1 , Xiaoyuan Chen 2, 3, 4, 5 , Rui Tian 1
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2023-05-10 , DOI: 10.1002/adhm.202300537
Xin Feng 1 , Long Wei 1 , Yanlin Liu 1 , Xiaoyuan Chen 2, 3, 4, 5 , Rui Tian 1
Affiliation
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Fluorescence imaging (FLI), a non-invasive, real-time, and highly sensitive imaging modality, allows for investigating the molecular/cellular level activities to understand physiological functions and diseases. The emergence of the second near-infrared window (NIR-II, 1000–1700 nm) has endowed fluorescence imaging with deeper tissue penetration and unprecedented clarity. Among the various NIR-II imaging fluorophores, the organic fluorescent probes have occupied a pivotal position in bioimaging due to their higher biocompatibility, safety, and potential for clinical applications compared with those of the inorganic probes. To obtain high-quality organic dyes, diverse strategies have been taken. In this review, different strategies for optimizing NIR-II organic fluorophores are summarized, including traditional chemical modifications, and emerging bioengineering operations, which have not previously been elaborated on and summarized. Moreover, the bioengineering strategies are highlighted using endogenous serum proteins and even exogenous gene-editing proteins, which would provide fresh insights to design good-performance dyes and help develop NIR-II probes with clinical translation potential in the future. A critical perspective on the direction of the design strategies of NIR-II dyes for disease imaging is also proposed.
中文翻译：
开发 NIR-II 成像荧光团的精心策划的策略
荧光成像 (FLI) 是一种非侵入性、实时且高度灵敏的成像方式，可以研究分子/细胞水平的活动以了解生理功能和疾病。第二个近红外窗口（NIR-II，1000-1700 nm）的出现赋予荧光成像更深的组织穿透力和前所未有的清晰度。在各种NIR-II成像荧光团中，有机荧光探针由于其与无机探针相比具有更高的生物相容性、安全性和临床应用潜力，在生物成像中占据着举足轻重的地位。为了获得高质量的有机染料，人们采取了多种策略。在这篇综述中，总结了优化 NIR-II 有机荧光团的不同策略，包括传统的化学修饰和新兴的生物工程操作，这些策略以前没有详细阐述和总结。此外，生物工程策略强调使用内源血清蛋白甚至外源基因编辑蛋白，这将为设计高性能染料提供新的见解，并有助于开发未来具有临床转化潜力的NIR-II探针。还对用于疾病成像的 NIR-II 染料的设计策略方向提出了批判性的观点。
更新日期：2023-05-10
中文翻译：
开发 NIR-II 成像荧光团的精心策划的策略
荧光成像 (FLI) 是一种非侵入性、实时且高度灵敏的成像方式，可以研究分子/细胞水平的活动以了解生理功能和疾病。第二个近红外窗口（NIR-II，1000-1700 nm）的出现赋予荧光成像更深的组织穿透力和前所未有的清晰度。在各种NIR-II成像荧光团中，有机荧光探针由于其与无机探针相比具有更高的生物相容性、安全性和临床应用潜力，在生物成像中占据着举足轻重的地位。为了获得高质量的有机染料，人们采取了多种策略。在这篇综述中，总结了优化 NIR-II 有机荧光团的不同策略，包括传统的化学修饰和新兴的生物工程操作，这些策略以前没有详细阐述和总结。此外，生物工程策略强调使用内源血清蛋白甚至外源基因编辑蛋白，这将为设计高性能染料提供新的见解，并有助于开发未来具有临床转化潜力的NIR-II探针。还对用于疾病成像的 NIR-II 染料的设计策略方向提出了批判性的观点。
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