The catalyst-free electrochemical halogenation and trifluoromethylation of 4H-pyrido[1,2-a]pyrimidin-4-ones with cheap and commercially available sodium salts have been developed under external oxidant-free conditions. The reaction shows broad scope of substrates, high regioselectivity, and good functional group compatibility. Importantly, the electrosynthesis of 4H-pyrido[1,2-a]pyrimidin-4-ones represents a green and advantageous alternative to traditional synthetic methods.

中文翻译：

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4H-吡啶并[1,2-a]嘧啶-4-酮的无催化剂和无氧化剂电化学区域选择性卤化和三氟甲基化

已开发出在无外部氧化剂的条件下用廉价且市售的钠盐进行 4 H-吡啶并[1,2- a ]嘧啶-4-酮的无催化剂电化学卤化和三氟甲基化。该反应显示出底物范围广、区域选择性高、官能团相容性好。重要的是，4 H-吡啶并[1,2- a ]嘧啶-4-酮的电合成代表了传统合成方法的绿色且有利的替代方法。