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Antibacterial Conductive Collagen-Based Hydrogels for Accelerated Full-Thickness Wound Healing
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-05-05 , DOI: 10.1021/acsami.2c22932 Xianyu Lin 1 , Xue Yang 1 , Panyu Li 1 , Zhilang Xu 1 , Lei Zhao 2 , Changdao Mu 1 , Defu Li 1 , Liming Ge 1
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-05-05 , DOI: 10.1021/acsami.2c22932 Xianyu Lin 1 , Xue Yang 1 , Panyu Li 1 , Zhilang Xu 1 , Lei Zhao 2 , Changdao Mu 1 , Defu Li 1 , Liming Ge 1
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Antibacterial conductive hydrogels have been extensively utilized in tissue repair and regeneration on account of their unique electrochemical performances and advantages of anti-pathogenic bacterial infection. Here, multi-functional collagen-based hydrogels (CHLY) with adhesivity, conductivity, and antibacterial and antioxidant activities were developed by introducing cysteine-modified ε-poly(l-lysine) (ε-PL-SH) and in situ-polymerized polypyrrole (PPy) nanoparticles to induce full-thickness wound healing. CHLY hydrogels have a low swelling ratio, good compressive strength, and viscoelasticity due to chemical crosslinking, chelation, physical interaction, and nano-reinforcements in the matrix network of hydrogels. CHLY hydrogels possess excellent tissue adhesion ability, low cytotoxicity, enhanced cell migration ability, and good blood coagulation performance without causing hemolysis. Interestingly, the chemical conjugation of ε-PL-SH in the hydrogel matrix gives hydrogels an inherently robust and broad-spectrum antibacterial activity, while the introduction of PPy endows hydrogels with superior free radical scavenging capacity and good electroactivity. Significantly, CHLY hydrogels have advantages in alleviating persistent inflammatory response as well as promoting angiogenesis, epidermis regeneration, and orderly collagen deposition at the wound sites through their multi-functional synergies, thus effectively accelerating full-thickness wound healing and improving wound healing quality. Overall, our developed multi-functional collagen-based hydrogel dressing demonstrates promising application prospects in the field of tissue engineering to induce skin regeneration.
中文翻译：
用于加速全层伤口愈合的抗菌导电胶原基水凝胶
抗菌导电水凝胶以其独特的电化学性能和抗病原菌感染的优势，被广泛应用于组织修复和再生。在这里，通过引入半胱氨酸修饰的 ε-poly( l-赖氨酸) (ε-PL-SH) 和原位聚合的聚吡咯 (PPy) 纳米粒子诱导全层伤口愈合。由于水凝胶基质网络中的化学交联、螯合、物理相互作用和纳米增强，CHLY 水凝胶具有低溶胀率、良好的抗压强度和粘弹性。CHLY水凝胶具有优异的组织粘附能力、低细胞毒性、增强的细胞迁移能力、良好的凝血性能而不引起溶血。有趣的是，ε-PL-SH 在水凝胶基质中的化学偶联赋予水凝胶固有的稳健和广谱抗菌活性，而 PPy 的引入赋予水凝胶优异的自由基清除能力和良好的电活性。显著地，CHLY水凝胶通过其多功能协同作用，在缓解持续性炎症反应、促进创面血管生成、表皮再生、胶原蛋白有序沉积等方面具有优势，从而有效加速创面全层愈合，提高创面愈合质量。总的来说，我们开发的多功能胶原基水凝胶敷料在组织工程领域展示了良好的应用前景，以诱导皮肤再生。
更新日期：2023-05-05
中文翻译：
用于加速全层伤口愈合的抗菌导电胶原基水凝胶
抗菌导电水凝胶以其独特的电化学性能和抗病原菌感染的优势，被广泛应用于组织修复和再生。在这里，通过引入半胱氨酸修饰的 ε-poly( l-赖氨酸) (ε-PL-SH) 和原位聚合的聚吡咯 (PPy) 纳米粒子诱导全层伤口愈合。由于水凝胶基质网络中的化学交联、螯合、物理相互作用和纳米增强，CHLY 水凝胶具有低溶胀率、良好的抗压强度和粘弹性。CHLY水凝胶具有优异的组织粘附能力、低细胞毒性、增强的细胞迁移能力、良好的凝血性能而不引起溶血。有趣的是，ε-PL-SH 在水凝胶基质中的化学偶联赋予水凝胶固有的稳健和广谱抗菌活性，而 PPy 的引入赋予水凝胶优异的自由基清除能力和良好的电活性。显著地，CHLY水凝胶通过其多功能协同作用，在缓解持续性炎症反应、促进创面血管生成、表皮再生、胶原蛋白有序沉积等方面具有优势，从而有效加速创面全层愈合，提高创面愈合质量。总的来说，我们开发的多功能胶原基水凝胶敷料在组织工程领域展示了良好的应用前景，以诱导皮肤再生。
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