Germacrone, a kind of natural sesquiterpenoid compound, has been reported to exhibit many pharmacological properties, especially the anticancer effect. Many in vitro experiments have been performed on various cancer cell lines, trying to explore their anticancer mechanism. Aiming at investigating the anticancer effect of germacrone, this article reviews the extant information on existing literature about germacrone-related studies. The anticancer mechanisms and clinical usages of germacrone are summarized. Literature databases (such as PubMed and CNKI) are used to search the current studies and experimental research about the anticancer effect information of germacrone. Anticancer mechanism of germacrone includes cell cycle arrest inducing, programmed cell death (apoptosis, autophagy, pyroptosis and ferroptosis) inducing, and estrogen-related genes mediating. Structural modification and analogue design are worthy of further study in the future

中文翻译：

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姜黄属新型安全抗癌药物 Germacrone 的作用机制综述

Germacrone 是一种天然倍半萜化合物，已被报道具有许多药理特性，尤其是抗癌作用。人们对各种癌细胞系进行了许多体外实验，试图探索它们的抗癌机制。本文旨在探讨吉马酮的抗癌作用，对现有吉马酮相关研究文献进行综述。综述了吉马酮的抗癌作用机制及临床应用。通过文献数据库（如PubMed、CNKI）检索吉马酮抗癌作用的现状研究和实验研究信息。吉马酮的抗癌机制包括诱导细胞周期停滞、诱导程序性细胞死亡（细胞凋亡、自噬、焦亡和铁死亡）以及雌激素相关基因的介导。结构修改和模拟设计值得未来进一步研究