甘氨酸相变的研磨方法,ACS Omega

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甘氨酸相变的研磨方法
ACS Omega ( IF 3.7 ) Pub Date : 2023-05-04 , DOI: 10.1021/acsomega.3c01435
Jeongki Kang _{1,

2} , Jinsoo Kim ₁ , Woo-Sik Kim ₁

Affiliation

甘氨酸具有三种多晶型、两种亚稳相（α-甘氨酸、β-甘氨酸）和一种稳定相（γ-甘氨酸）。然而，甘氨酸从α相到γ相的相变是众所周知的动力学不利过程。在这项研究中，提出了一种简单有效的甘氨酸从 α 相到 γ 相相变的研磨方法。在水溶液中，α-甘氨酸和 γ-甘氨酸的体积溶解度分别为 180 和 ~172 g/L。然而，根据 Ostwald-Freundlich 方程，随着 α-甘氨酸的晶体尺寸通过研磨减小至 ~0.6 μm，α-甘氨酸的饱和浓度从 180 g/L 增加到 191 g/L。只要溶液浓度超过临界点（σ=0.1），就可以通过研磨溶液中的α-甘氨酸晶体来突然诱导γ-甘氨酸成核。随后，在没有添加剂的情况下实现了 α 相到 γ 相的完全转变。类似地，研磨方法对于在冷却结晶中产生γ-甘氨酸晶体是有效的，而α-甘氨酸晶体总是在冷却结晶中产生而无需研磨。这项研究表明，物理研磨可以通过触发稳定多晶型物的成核来有效地促进相变。

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Grinding Method for Phase Transformation of Glycine

Glycine had three polymorphs, two metastable phases (α-glycine, β-glycine) and one stable phase (γ-glycine). However, the phase transformation of glycine from α-phase to γ-phase was well known as the kinetically unfavorable process. In this study, a simple and effective grinding method for phase transformation of glycine from α-phase to γ-phase is proposed. In an aqueous solution, α-glycine and γ-glycine had bulk solubilities of 180 and ∼172 g/L, respectively. According to the Ostwald–Freundlich equation, however, as the crystal size of α-glycine was reduced to ∼0.6 μm by grinding, the saturated concentration of α-glycine increased from 180 to 191 g/L. As long as the solution concentration exceeds a critical point (σ = 0.1), it can be possible to suddenly induce the nucleation of γ-glycine by grinding the α-glycine crystal in the solution. Subsequently, the complete transformation of α-phase to γ-phase was achieved without additives. Similarly, the grinding method was effective for producing the γ-glycine crystal in the cooling crystallization whereas the α-glycine crystal was always produced in the cooling crystallization without grinding. This study showed that physical grinding can effectively facilitate phase transformation by triggering the nucleation of stable polymorph.

更新日期：2023-05-04

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