Enantioselective Synthesis of N−N Biaryl Atropisomers through Iridium(I)-Catalyzed C−H Alkylation with Acrylates,Angewandte Chemie International Edition

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Enantioselective Synthesis of N−N Biaryl Atropisomers through Iridium(I)-Catalyzed C−H Alkylation with Acrylates
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-05-04 , DOI: 10.1002/anie.202305067
Si-Yong Yin ₁ , Qiansujia Zhou _{1,

2} , Chen-Xu Liu ₁ , Qing Gu _{1,

2} , Shu-Li You ₁

Affiliation

A highly efficient iridium-catalyzed asymmetric C−H alkylation reaction is described. A series of structurally diverse indole-pyrrole and pyrrole-pyrrole N−N atropisomers were obtained in good yields (up to 98 %) with excellent enantioselectivity (up to 99 % ee). This reaction features perfect atom economy, wide substrate scope, and multifunctionalized products allowing diverse transformations.

中文翻译：

通过铱（I）催化丙烯酸酯的 CH 烷基化对映选择性合成 N−N 联芳基阻转异构体

描述了一种高效的铱催化不对称 CH 烷基化反应。以良好的收率（高达 98%）和优异的对映选择性（高达 99% ee）获得了一系列结构多样的吲哚-吡咯和吡咯-吡咯 N−N 阻转异构体。该反应具有完美的原子经济性、广泛的底物范围以及允许多种转化的多功能化产物。

更新日期：2023-05-04

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