Nickel-Catalyzed C−I-Selective C(sp2)−C(sp3) Cross-Electrophile Coupling of Bromo(iodo)arenes with Alkyl Bromides,Angewandte Chemie International Edition

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Nickel-Catalyzed C−I-Selective C(sp2)−C(sp3) Cross-Electrophile Coupling of Bromo(iodo)arenes with Alkyl Bromides
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-05-03 , DOI: 10.1002/anie.202304177
Xiaoyuan Ying _{1,

2} , Yuxi Li _{1,

2} , Luyang Li ₂ , Chao Li _{1,

2}

Affiliation

A method for the C(sp²)−I selective cross-electrophile coupling (XEC) of bromo(iodo)arenes with 3°, 2°, and 1°alkyl bromides is reported. This mild XEC displays a broad scope with demonstrated functional group tolerance and finds use in the streamlined preparation of synthetically challenging bioactive compounds. Given the prevalence of its building blocks and the substrate generality, this discovery will likely inspire numerous applications.

中文翻译：

溴（碘）芳烃与烷基溴化物的镍催化 C−I 选择性 C(sp2)−C(sp3) 交叉亲电偶联

报道了溴（碘）芳烃与 3°、2° 和 1° 烷基溴化物的C( sp ² )-I 选择性交叉亲电偶联 (XEC)的方法。这种温和的 XEC 显示出广泛的范围和已证明的官能团耐受性，并可用于简化合成具有挑战性的生物活性化合物的制备。鉴于其构建模块的普遍性和底物的普遍性，这一发现可能会激发大量应用。

更新日期：2023-05-03

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