CD83+ B 细胞通过 sCD83 抑制 DC 缓解葡萄膜炎,Immunology

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CD83+ B 细胞通过 sCD83 抑制 DC 缓解葡萄膜炎
Immunology ( IF 4.9 ) Pub Date : 2023-05-03 , DOI: 10.1111/imm.13654
Meng Feng _{1,

2,

3} , Xin Wang _{4,

5} , Shuping Zhou _{1,

2,

3} , Minghao Li _{1,

2,

3} , Tingting Liu ₆ , Xunbin Wei _{7,

8,

9,

10,

11} , Wei Lin _{1,

2,

3}

Affiliation

Department of Rheumatology and Autoimmunology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
School of Clinical and Basic Medicine, Shandong First Medical University &Shandong Academy of Medical Sciences, Jinan, China.
Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Medicine and Health Key Laboratory of Rheumatism, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.
Department of Clinical Laboratory, Qilu Hospital, Shandong University, Jinan, China.
Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application, Jinan, China.
Shandong Eye Hospital, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Biomedical Engineering Department, Peking University, Beijing, China.
School of Biomedical Engineering, Anhui Medical University, Hefei, China.
Institute of Medical Technology, Peking University Health Science Center, Beijing, China.
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, China.
International Cancer Institute, Peking University, Beijing, China.

可溶性CD83（sCD83）在许多自身免疫性疾病中发挥免疫抑制功能，包括实验性自身免疫性葡萄膜炎（EAU），但所涉及的细胞和机制尚不清楚。本研究表明CD83 ⁺ B细胞是sCD83的主要来源。它们缓解了 EAU 的症状，并降低了眼睛和淋巴结中 T 细胞和 DC 的百分比。这些 CD83 ⁺ B 细胞通过 sCD83 减少 DC 的 IL-1β、IL-18 和 IFN-γ 分泌。sCD83 与 DC 中的 GTPase Ras 相关蛋白 (Rab1a) 相互作用，促进 Rab1a 在自溶酶体中积累，并抑制 mTORC1 磷酸化和 NLRP3 表达。因此，CD83 ⁺ B细胞通过分泌sCD83在EAU中发挥调节作用。^{CD83 +} B细胞缺乏调节可能是导致自身免疫性葡萄膜炎患者免疫过度激活的重要因素。CD83 ^{+ B 细胞抑制葡萄膜炎中活化的 DC，表明 CD83}⁺ B 细胞在葡萄膜炎中的潜在治疗作用。

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更新日期：2023-05-03

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