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Chemiluminescent carbon nanodots for dynamic and guided antibacteria
Light: Science & Applications ( IF 20.6 ) Pub Date : 2023-05-04 , DOI: 10.1038/s41377-023-01149-8
Jiang-Fan Han 1 , Qing Lou 1 , Zhong-Zheng Ding 1 , Guang-Song Zheng 1 , Qing-Chao Ni 1 , Run-Wei Song 1 , Kai-Kai Liu 1 , Jin-Hao Zang 1 , Lin Dong 1 , Cheng-Long Shen 1 , Chong-Xin Shan 1
Affiliation  

Advanced antibacterial technologies are needed to counter the rapid emergence of drug-resistant bacteria. Image-guided therapy is one of the most promising strategies for efficiently and accurately curing bacterial infections. Herein, a chemiluminescence (CL)-dynamic/guided antibacteria (CDGA) with multiple reactive oxygen species (ROS) generation capacity and chemiexcited near-infrared emission has been designed for the precise theranostics of bacterial infection by employing near-infrared emissive carbon nanodots (CDs) and peroxalate as CL fuels. Mechanistically, hydrogen peroxide generated in the bacterial microenvironment can trigger the chemically initiated electron exchange between CDs and energy-riched intermediate originated from the oxidized peroxalate, enabling bacterial induced inflammation imaging. Meanwhile, type I/II photochemical ROS production and type III ultrafast charge transfer from CDs under the self-illumination can inhibit the bacteria proliferation efficiently. The potential clinical utility of CDGA is further demonstrated in bacteria infected mice trauma model. The self-illuminating CDGA exhibits an excellent in vivo imaging quality in early detecting wound infections and internal inflammation caused by bacteria, and further are proven as efficient broad-spectrum antibacterial nanomedicines without drug-resistance, whose sterilizing rate is up to 99.99%.



中文翻译:

用于动态和引导抗菌的化学发光碳纳米点

需要先进的抗菌技术来对抗耐药细菌的迅速出现。图像引导治疗是最有前途的有效和准确治疗细菌感染的策略之一。在此,设计了一种具有多种活性氧(ROS)产生能力和化学激发近红外发射的化学发光(CL)动态/引导抗菌(CDGA),通过使用近红外发射碳纳米点来精确治疗细菌感染( CDs) 和过草酸盐作为 CL 燃料。从机制上讲,细菌微环境中产生的过氧化氢可以触发 CD 与源自氧化过草酸盐的富含能量的中间体之间的化学引发的电子交换,从而实现细菌诱导的炎症成像。同时,I/II 型光化学 ROS 的产生和 CD 在自发光下的 III 型超快电荷转移可以有效抑制细菌增殖。CDGA 的潜在临床效用在细菌感染的小鼠创伤模型中得到进一步证明。自发光CDGA在早期检测细菌引起的伤口感染和内部炎症方面表现出优异的体内成像质量,进一步被证明是高效的广谱抗菌纳米药物,无耐药性,杀菌率高达99.99%。

更新日期:2023-05-04
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