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Endothelium-Mimetic Surface Modification Improves Antithrombogenicity and Enhances Patency of Vascular Grafts in Rats and Pigs
JACC: Basic to Translational Science ( IF 8.4 ) Pub Date : 2023-05-03 , DOI: 10.1016/j.jacbts.2022.12.009
Yongzhen Wei 1, 2 , Huan Jiang 2 , Chao Chai 3 , Pei Liu 2 , Meng Qian 2 , Na Sun 4 , Man Gao 1 , Honglin Zu 5 , Yongquan Yu 6 , Guangbo Ji 2 , Yating Zhang 2 , Sen Yang 5 , Ju He 5 , Jiansong Cheng 1 , Jinwei Tian 4 , Qiang Zhao 2
Affiliation  

We first identified thrombomodulin (TM) and endothelial nitric oxide (NO) synthase as key factors for the antithrombogenic function of the endothelium in human atherosclerotic carotid arteries. Then, recombinant TM and an engineered galactosidase responsible for the conversion of an exogenous NO prodrug were immobilized on the surface of the vascular grafts. Surface modification by TM and NO cooperatively enhanced the antithrombogenicity and patency of vascular grafts. Importantly, we found that the combination of TM and NO also promoted endothelialization, whereas it reduced adverse intimal hyperplasia, which is critical for the maintenance of vascular homeostasis, as confirmed in rat and pig models.



中文翻译:

内皮模拟表面修饰可提高大鼠和猪的抗血栓形成性并增强血管移植物的通畅性

我们首先确定血栓调节蛋白(TM)和内皮一氧化氮(NO)合酶是人动脉粥样硬化颈动脉内皮抗血栓形成功能的关键因素。然后,将重组TM和负责转化外源NO前药的工程化半乳糖苷酶固定在血管移植物的表面上。TM和NO的表面修饰协同增强血管移植物的抗血栓形成性和通畅性。重要的是,我们发现TM和NO的组合还促进内皮化,同时减少不良内膜增生,这对于维持血管稳态至关重要,这一点在大鼠和猪模型中得到证实。

更新日期:2023-05-03
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