Electrochemical intramolecular N(sp2)–H/N(sp3)–H coupling for the synthesis of 1H-indazoles,Green Chemistry

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Electrochemical intramolecular N(sp2)–H/N(sp3)–H coupling for the synthesis of 1H-indazoles
Green Chemistry ( IF 9.3 ) Pub Date : 2023-05-02 , DOI: 10.1039/d3gc00380a
Qiang Zhong ₁ , Pei-Long Wang _{1,

2} , Hui Gao _{1,

3} , Fang Ma ₁ , Youqing Yang ₁ , Hongji Li ₁

Affiliation

The electrochemical synthesis of 1H-indazoles via an intramolecular N(sp²)–H/N(sp³)–H coupling reaction at room temperature is first described. The transition metal-free electrochemical cyclization features the use of commercially available NH₃ as the nitrogen source and a broad substrate scope, thus affording a wide range of substituted 1H-indazoles in moderate to good yields. Both the control experiments and mechanistic studies support the proposed reaction mechanism for this electrochemical cyclization.

中文翻译：

电化学分子内 N(sp2)–H/N(sp3)–H 偶联合成 1H-吲唑

首先描述了在室温下通过分子内 N(sp ² )–H/N(sp ³ )–H 偶联反应电化学合成 1 H-吲唑。无过渡金属电化学环化的特点是使用市售的 NH ₃作为氮源和广泛的底物范围，从而以中等到良好的产率提供范围广泛的取代 1 H-吲唑。控制实验和机理研究都支持所提出的这种电化学环化反应机理。

更新日期：2023-05-02

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