Poorly differentiated adenosquamous carcinoma (glassy cell carcinoma) of the cervix is extremely rare, accounting for 1–2% of all cervical cancers. Herein, we report a case with coexistent poorly differentiated adenosquamous carcinoma (glassy cell carcinoma), “usual-type” adenocarcinoma, and squamous cell carcinoma in situ of the cervix. A female patient in her 60 s was referred to our hospital and diagnosed with poorly differentiated adenosquamous carcinoma based on cervical cytology and biopsy. The tumor was classified as clinical stage IB1 cervical cancer following magnetic resonance imaging; radical hysterectomy was performed. Histopathological examination revealed poorly differentiated adenosquamous carcinoma (glassy cell carcinoma), usual-type adenocarcinoma, and squamous cell carcinoma in situ, all coexisting. All carcinoma regions showed identical sizes to high-risk human papillomavirus (HPV) in fragment analysis. The patient is currently alive, without evidence of recurrence, 31 months post surgery. In this case, three different carcinomas coexisted. Fragment analysis of the patient’s HPV status suggested that all carcinomas were related to an infection with the same high-risk HPV type. To determine the precise mechanism of tumor development, i.e., whether the tumors were of the mixed or collision type, further studies are needed, including clonal analysis for the loss of heterozygosity pattern.

宫颈低分化腺鳞癌（玻璃细胞癌）极为罕见，占所有宫颈癌的 1-2%。在此，我们报告一例同时存在低分化腺鳞癌（玻璃细胞癌）、“普通型”腺癌和宫颈原位鳞状细胞癌的病例。一名60多岁的女性患者被转诊到我院，根据宫颈细胞学和活检诊断为低分化腺鳞癌。磁共振成像后肿瘤被分类为临床IB1期宫颈癌；进行了根治性子宫切除术。组织病理学检查发现低分化腺鳞癌（玻璃细胞癌）、普通型腺癌和原位鳞状细胞癌并存。在片段分析中，所有癌区域的大小均与高危人乳头瘤病毒 (HPV) 相同。术后 31 个月，患者目前还活着，没有复发的证据。在这种情况下，三种不同的癌症共存。对患者 HPV 状态的片段分析表明，所有癌症都与相同高危 HPV 类型的感染有关。为了确定肿瘤发展的精确机制，即肿瘤是混合型还是碰撞型，需要进一步的研究，包括杂合性模式丢失的克隆分析。