Metal-organic frameworks (MOFs) exhibited huge application potential in electrochemical analysis field, how to facilely and effectively boost the electrochemical sensing activity of MOFs materials still face enormous challenges. In this work, core-shell Co-MOF (Co-TCA@ZIF-67) polyhedrons with hierarchical porosity was easily synthesized via simple chemical etching reaction by selecting thiocyanuric acid as the etching reagent. Benefiting from the introduction of mesopores and thiocyanuric acid/Co²⁺ complex on the surface of ZIF-67 frameworks, the property and functions of the pristine ZIF-67 was seriously tailored. Compared with the pristine ZIF-67, the as-resulted Co-TCA@ZIF-67 nanoparticles displayed greatly enhanced physical adsorption capacity and electrochemical reduction activity toward the antibiotic drug furaltadone. As a result, a novel furaltadone electrochemical sensor with high sensitivity was fabricated. The linear detection range was from 50 nM to 5 μM with sensitivity of 110.40 μA⁻¹ μM⁻¹ cm⁻² and detection limit of 12 nM. This work demonstrated chemical etching strategy is truly a facile and effective way to modify the electrochemical sensing performance of MOFs-based materials, and we believed the chemically etched MOFs materials will play a stronger role in terms of food safety and environmental conservation.

金属有机骨架材料（MOFs）在电化学分析领域展现出巨大的应用潜力，如何简便有效地提高MOFs材料的电化学传感活性仍面临巨大挑战。在这项工作中，通过选择硫氰尿酸作为蚀刻试剂，通过简单的化学蚀刻反应，很容易合成具有分级孔隙率的核-壳 Co-MOF (Co-TCA@ZIF-67) 多面体。^{受益于介孔和硫氰尿酸/Co 2+}的引入ZIF-67 框架表面复杂，原始 ZIF-67 的特性和功能经过认真定制。与原始的 ZIF-67 相比，所得 Co-TCA@ZIF-67 纳米粒子对抗生素药物呋喃他酮显示出显着增强的物理吸附能力和电化学还原活性。结果，制备了一种新型的高灵敏度呋喃他酮电化学传感器。线性检测范围为 50 nM 至 5 μM，灵敏度为 110.40 μA ^-1  μM ^-1  cm ^-2检测限为 12 nM。这项工作表明化学蚀刻策略确实是一种简便有效的改变 MOFs 基材料电化学传感性能的方法，我们相信化学蚀刻的 MOFs 材料将在食品安全和环境保护方面发挥更大的作用。