Talanta ( IF 5.6 ) Pub Date : 2023-04-28 , DOI: 10.1016/j.talanta.2023.124584
Hongyuan Shang 1 , Xiaofei Zhang 1 , Meili Ding 1 , Aiping Zhang 1
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Detection of biomarkers is very vital in the prevention, diagnosis and treatment of diseases. However, due to the poor accuracy and sensitivity of the constructed biosensors, we are now facing great challenges. In addressing these problems, nanohybrid-based dual mode biosensors including optical-optical, optical-electrochemical and electrochemical-electrochemical have been developed to detect various biomarkers. Integrating the merits of nanomaterials with abundant active sites, synergy and excellent physicochemical properties, many bi-functional nanohybrids have been reasonable designed and controllable preparation, which applied to the construction dual mode biosensors. Despite the significant progress, further efforts are still needed to develop dual mode biosensors and ensure their practical application by using portable digital devices. Therefore, the present review summarizes an in-depth evaluation of the bi-functional nanohybrids assisted dual mode biosensing platform of biomarkers. We are hoping this review could inspire further concepts in developing novel dual mode biosensors for possible detection application.
中文翻译:
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基于双功能杂化纳米材料协同效应的双模生物传感器平台
生物标志物的检测对于疾病的预防、诊断和治疗至关重要。然而,由于构建的生物传感器的准确性和灵敏度较差,我们现在面临着巨大的挑战。为了解决这些问题,已经开发了基于纳米杂化物的双模式生物传感器,包括光学-光学、光电-电化学和电化学-电化学,以检测各种生物标志物。结合纳米材料具有丰富的活性位点、协同作用和优异的理化性质等优点,许多双功能纳米杂化物经过合理设计和可控制备,应用于构建双模式生物传感器。尽管取得了重大进展,但仍需要进一步努力开发双模式生物传感器,并通过使用便携式数字设备确保其实际应用。因此,本综述总结了对双功能纳米杂化物辅助生物标志物双模式生物传感平台的深入评估。我们希望这篇综述能够激发进一步的概念,为可能的检测应用开发新型双模式生物传感器。