Cu?Ce?O双金属氧化物通过微波强化微波催化和芬顿疗法快速治疗金黄色葡萄球菌感染的骨髓炎,Small Methods

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Cu?Ce?O双金属氧化物通过微波强化微波催化和芬顿疗法快速治疗金黄色葡萄球菌感染的骨髓炎
Small Methods ( IF 10.7 ) Pub Date : 2023-04-28 , DOI: 10.1002/smtd.202300203
Wenchan Sun ₁ , Chaofeng Wang ₂ , Danya Wan ₁ , Yufeng Zheng ₃ , Shuilin Wu ₃ , Jie Shen ₄ , Yu Zhang ₅ , Xiangmei Liu _{1,

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Affiliation

细菌引起的骨髓炎是一种深部病变，临床上常采用抗生素治疗。长期使用抗生素可能会使细菌产生耐药性。在这里，CuCeO _x材料用于通过微波（MW）辅助杀灭细菌来治疗传染性细菌性骨髓炎。材料在MW照射下的介电特性会产生热量，并且材料在MW照射下会产生活性氧（ROS）。热和ROS增加了细菌细胞膜的热敏感性和通透性，释放的铜离子很容易穿透细菌膜并与H ₂ O ₂反应，在细菌内部产生有毒的羟基，导致细菌最终死亡。这是由于MW热效应、ROS的协同作用以及细菌内部平衡的打破。CuCeO _x可以利用微波照射有效治疗金黄色葡萄球菌引起的骨髓炎。这项研究通过揭示非侵入性抗菌系统并使用微波热疗法和微波动力学来实现治疗结果，可以安全有效地应对深部组织感染的挑战。

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Cu?Ce?O Bimetallic Oxide Rapidly Treats Staphylococcus aureus-Infected Osteomyelitis through Microwave Strengthened Microwave Catalysis and Fenton-Therapy

Osteomyelitis caused by bacteria is a deep-seated lesion and is often treated clinically with antibiotics. Long-term use of antibiotics may predispose bacteria to develop resistance. Here, CuCeO_x material is applied to treat infectious bacterial osteomyelitis using microwave (MW)-assisted bacterial killing. Heat generation occurs as a result of the dielectric properties of the material under MW irradiation, and the material generates reactive oxygen species (ROS) under MW irradiation. Heat and ROS increase the thermal sensitivity and permeability of bacterial cell membranes, and the released copper ions easily penetrate the bacterial membrane and react with H₂O₂ to produce a toxic hydroxyl group inside the bacteria, leading to the bacteria's eventual death. This is due to the synergistic effect of the MW thermal effect, ROS, and the breaking of the equilibrium within the bacteria. CuCeO_x can effectively treat osteomyelitis caused by Staphylococcus aureus using MW irradiation. This study can safely and effectively address the challenge of deep tissue infections by shedding light on non-invasive antimicrobial systems and using MW thermal therapy and MW dynamics to achieve therapeutic results.

更新日期：2023-04-28

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