ZnP-Coated Zn?1Cu?0.1Ti Membrane with High Strength-Ductility, Antibacterial Ability, Cytocompatibility, and Osteogenesis for Biodegradable Guided Bone Regeneration Applications,Advanced Functional Materials

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ZnP-Coated Zn?1Cu?0.1Ti Membrane with High Strength-Ductility, Antibacterial Ability, Cytocompatibility, and Osteogenesis for Biodegradable Guided Bone Regeneration Applications
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2023-04-28 , DOI: 10.1002/adfm.202214657
Xian Tong _{1,

2} , Yue Han ₁ , Li Zhu ₁ , Runqi Zhou ₁ , Zhiqiang Lin ₁ , Hongning Wang ₁ , Shengbin Huang ₁ , Yuncang Li ₃ , Jianfeng Ma ₁ , Cuie Wen ₃ , Jixing Lin ₁

Affiliation

Zinc (Zn) and its alloys have recently gained research interest due to their good biosafety, biological function, biodegradability, and formability. Zinc-phosphate (ZnP) coating has been shown to improve the corrosion resistance and biocompatibility of Zn alloys. Here, a biodegradable ZnP-coating on Zn1Cu0.1Ti (ZCT) membrane with high strength-ductility and mechanical stability, suitable degradation rate, effective antibacterial ability, excellent in vitro and in vivo cytocompatibility, and osteogenesis is reported. The ZnP-coated ZCT exhibits high strength-ductility with a yield strength of 264 MPa, ultimate tensile strength of 312 MPa, elongation of 36.0%, and high mechanical stability before and after 30 d immersion in Hanks’ and AS solutions, all of which are higher than those of ZCT. The ZnP coating shows good deformation resistance, healing effect, and bond strength with the substrate, meeting the clinical contour shaping requirements. The ZnP-coated ZCT membrane sample shows higher cell viability toward MC3T3-E1 and MG-63 cells, osteogenic and mitochondrial quality-control properties in vitro than those of the ZCT sample. Using a rat calvarial defect model, the ZnP-coated ZCT membrane shows complete biosafety and considerable osteogenesis performance. Overall, the ZnP-coated ZCT membrane is recommended as a promising biodegradable implant material for oral guided bone regeneration application.

中文翻译：

ZnP 涂层 Zn?1Cu?0.1Ti 膜具有高强度延展性、抗菌能力、细胞相容性和成骨作用，适用于可生物降解的引导骨再生应用

锌（Zn）及其合金由于其良好的生物安全性、生物功能、生物降解性和成型性，近年来引起了人们的研究兴趣。磷酸锌 (ZnP) 涂层已被证明可以提高锌合金的耐腐蚀性和生物相容性。此处，Zn  1Cu 上有可生物降解的 ZnP 涂层据报道，0.1Ti（ZCT）膜具有高强度延展性和机械稳定性、合适的降解率、有效的抗菌能力、优异的体外和体内细胞相容性和成骨作用。ZnP涂层ZCT表现出高强度-延展性，屈服强度为264 MPa，极限拉伸强度为312 MPa，伸长率为36.0%，在Hanks'和AS溶液中浸泡30 d前后具有较高的机械稳定性，所有这些均高于ZCT。ZnP涂层具有良好的抗变形能力、愈合效果以及与基体的结合强度，满足临床轮廓塑形要求。与 ZCT 样品相比，ZnP 涂层的 ZCT 膜样品对 MC3T3-E1 和 MG-63 细胞表现出更高的细胞活力、体外成骨和线粒体质量控制特性。使用大鼠颅骨缺损模型，ZnP涂层的ZCT膜显示出完全的生物安全性和可观的成骨性能。总体而言，ZnP 涂层 ZCT 膜被推荐作为一种有前景的可生物降解植入材料，用于口腔引导骨再生应用。

更新日期：2023-04-28

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