Free Amino Group Transfer via α-Amination of Native Carbonyls,Angewandte Chemie International Edition

当前位置： X-MOL 学术 › Angew. Chem. Int. Ed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Free Amino Group Transfer via α-Amination of Native Carbonyls
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-04-28 , DOI: 10.1002/anie.202304990
Minghao Feng ₁ , Anthony J Fernandes _{1,

2} , Ana Sirvent _{1,

2} , Eleonora Spinozzi ₁ , Saad Shaaban ₁ , Nuno Maulide _{1,

2}

Affiliation

An amino group transfer strategy was developed to install free NH₂ to the α-position of native carbonyls under mild conditions. The resulting primary α-aminated products are amenable to in situ peptide coupling or Pictet–Spengler cyclization in one-pot procedures. We anticipate this method to provide a general platform towards the synthesis of amines, ultimately opening exciting avenues in the synthesis and medicinal study of peptidomimetics.

中文翻译：

通过天然羰基的 α-氨基化进行游离氨基转移

开发了氨基转移策略以在温和条件下将游离NH ₂安装到天然羰基的α位。所得初级 α-胺化产物适合在一锅程序中进行原位肽偶联或 Pictet-Spengler 环化。我们预计这种方法将为胺的合成提供一个通用平台，最终为肽模拟物的合成和医学研究开辟令人兴奋的途径。

更新日期：2023-04-28

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南