Natural products are one of the essential sources of innovative drugs. Trigothysoid N, a natural daphnane diterpenoid obtained from Trigonostemon thyrsoideus, possessed the strong ability to inhibit the proliferation of A549 cells. Besides interrupting the cell cycle, the mechanism examination revealed that trigothysoid N can inhibit tumor proliferation and migration by targeting mitochondria, regulating the STAT3/FAK signal pathway, and suppressing angiogenesis. In addition to the possible mechanism, in vivo antitumor experiments were performed to explore the potential of trigothysoid N for treating non-small cell lung cancer (NSCLC). Collectively, these findings supported the great potential of trigothysoid N as a hopeful therapeutic agent against NSCLC.

天然产物是创新药物的重要来源之一。Trigothysoid N 是从 Trigonostemon thyrsoideus 中提取的天然瑞香二萜类化合物，具有很强的抑制 A549 细胞增殖的能力。除了阻断细胞周期外，机制检测还揭示了trigothysoid N可以通过靶向线粒体、调节STAT3/FAK信号通路、抑制血管生成来抑制肿瘤增殖和迁移。除了可能的机制外，还进行了体内抗肿瘤实验，以探索 trigothysoid N 治疗非小细胞肺癌 (NSCLC) 的潜力。总的来说，这些发现支持了 trigothysoid N 作为一种有希望的 NSCLC 治疗剂的巨大潜力。