使用生物基离子液体水溶液的可持续角蛋白回收工艺及其技术经济评估,Green Chemistry

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使用生物基离子液体水溶液的可持续角蛋白回收工艺及其技术经济评估
Green Chemistry ( IF 9.3 ) Pub Date : 2023-04-27 , DOI: 10.1039/d3gc00850a
Cariny Polesca _{1,

2} , Amir Al Ghatta ₂ , Helena Passos ₁ , João A. P. Coutinho ₁ , Jason P. Hallett ₂ , Mara G. Freire ₁

Affiliation

角蛋白是一种生物聚合物，具有很高的生物材料生产潜力，主要研究用于组织工程应用的水凝胶和薄膜形式。为了找到可持续的溶剂并开发有效的角蛋白回收工艺，这项工作使用生物基离子液体 (IL) 的水溶液来溶解鸡毛。鸡毛完全溶解在醋酸胆碱水溶液中 ([N _111(2OH) ][C ₁ CO ₂]) 在固体：液体重量比为 1：20 w/w，100 °C 下进行 4 小时。进行实验设计以优化角蛋白回收条件，研究凝结剂溶剂、溶液：凝结剂重量比和时间。在最佳条件下（20.25 wt% 的乙醇水溶液，5 小时，溶液：凝结剂比例为 1 : 1.45 w/w），回收了 93 wt% 的角蛋白。IL 显示可在四个连续循环中重复使用，产率约为 95 wt%，并且角蛋白回收效率没有显着损失。_{这些结果表明 [N 111(2OH)} ][C ₁ CO ₂的水溶液] 可以导致有效的角蛋白回收，作为开发更有效和更环保的工艺从废物中回收生物聚合物的基础。由于开发过程的相关性，通过全面的敏感性分析进行了技术经济评估，评估了一个虚拟的运营生物精炼厂，并展示了一条可以通过开发的过程使生产的角蛋白商业化的途径。_{根据工艺模拟，角蛋白的最低售价为每公斤 22 美元，CO 2}排放量较小（4.04 kg _{CO ₂} kg_角蛋白⁻¹），使该工艺适用于生物医学和化妆品应用。

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Sustainable keratin recovery process using a bio-based ionic liquid aqueous solution and its techno-economic assessment

Keratin is a biopolymer with high potential for biomaterial production, being principally investigated in hydrogel and film forms for use in tissue-engineering applications. Aiming to find sustainable solvents and develop an efficient keratin recovery process, this work used an aqueous solution of bio-based ionic liquid (IL) for the dissolution of chicken feathers. Complete dissolution of chicken feathers in an aqueous solution of cholinium acetate ([N_111(2OH)][C₁CO₂]) was conducted at a solid : liquid weight ratio of 1 : 20 w/w, 100 °C for 4 h. An experimental design was carried out to optimize the keratin recovery conditions, investigating coagulant solvent, solution : coagulant weight ratio, and time. Under the optimal conditions (20.25 wt% of ethanol in water, 5 h, and solution : coagulant ratio of 1 : 1.45 w/w), 93 wt% of keratin was recovered. The IL was shown to be reusable in four successive cycles, with a yield of around 95 wt% and no significant losses in the efficiency of keratin recovery. These results demonstrate that an aqueous solution of [N_111(2OH)][C₁CO₂] can lead to effective keratin recovery, serving as the basis for the development of a more effective and environmentally friendly process to recover biopolymers from waste. Due to the relevance of the developed process, techno-economic assessment through a comprehensive sensitivity analysis was carried out, evaluating a virtual operating biorefinery and showing a pathway that can enable the commercialization of produced keratin by the developed process. According to the process simulation, the minimum selling price for keratin is 22 $ per kg, with a small positive CO₂ emission (4.04 kg_CO₂ kg_keratin⁻¹), making this process suitable for biomedical and cosmetic applications.

更新日期：2023-05-02

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