单原子金属氮碳催化剂为生物传感的单分子检测提供能量,InfoMat

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单原子金属氮碳催化剂为生物传感的单分子检测提供能量
InfoMat ( IF 22.7 ) Pub Date : 2023-04-24 , DOI: 10.1002/inf2.12421
Xianyang Zhang _{1,

2} , Pengfei Chen _{1,

2} , Siwuxie He ₃ , Bowen Jiang ₁ , Yong Wang _{1,

2} , Yonghua Cheng ₁ , Jian Peng ₁ , Francis Verpoort ₁ , John Wang _{4,

5} , Zongkui Kou ₁

Affiliation

以单分子检测为特色的生物传感器为食品安全检测、疾病诊断和环境监测带来了巨大的机遇和挑战。单分子检测很大程度上缺乏足够高的活性、精确的分子选择性以及对确切操作机制的理解。单原子催化剂（SAC），特别是那些模仿天然金属酶结构的金属-氮-碳催化剂，具有明确的金属原子键构型、高水平的分子选择性、易于制造，赋予单分子检测实用性可行性。单原子催化剂的最新进展也为关键机制的理解提供了新的途径。在这篇简短的评论中，我们将首先了解最近才在分子级生物传感器中探索的 SAC 的简要历史和优势，它们与纳米酶和天然金属酶有相似之处，也有不同之处。然后通过重点关注实现局部配位调制信号放大的不同分子尺度传感模式，全面讨论它们在电化学、光化学和光电化学传感器中的应用。最后，我们确定了这些基于 SAC 的单分子检测在生物传感器的进一步发展中面临的新机遇和挑战。然后通过重点关注实现局部配位调制信号放大的不同分子尺度传感模式来全面讨论光电化学传感器。最后，我们确定了这些基于 SAC 的单分子检测在生物传感器的进一步发展中面临的新机遇和挑战。然后通过重点关注实现局部配位调制信号放大的不同分子尺度传感模式来全面讨论光电化学传感器。最后，我们确定了这些基于 SAC 的单分子检测在生物传感器的进一步发展中面临的新机遇和挑战。

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Single-atom metal-nitrogen-carbon catalysts energize single molecule detection for biosensing

Biosensors featuring single molecule detection present huge opportunities as well as challenges in food safety inspection, disease diagnosis, and environmental monitoring. Single-molecule detection is largely lacking of high enough activity, precision molecule selectivity, and understanding in the exact operating mechanism. Single-atom catalysts (SACs), especially those metals-nitrogen-carbon that mimic the natural metalloenzyme structure, and with well-defined metal atom bond configurations, high level of molecular selectivity, and easy fabrication, endow single molecule detections with practical-use feasibilities. The recent advances in single-atom catalysts also present new pathways in the key mechanism understandings. In this short review, we will first visit the brief history and advantages of SACs that have been explored only recently for molecule-scale biosensors, where they are analogous and also differentiated from those nanozymes and natural metalloenzymes. Their applications in electrochemical, photochemical, and photoelectrochemical sensors are then discussed comprehensively by focusing on the different molecule-scale sensing modes in achieving local coordination-modulated signal amplifications. Finally, we identify new opportunities and challenges faced by these SACs-based single molecule detections in the further development of biosensors.

更新日期：2023-04-24

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