Highly Elastic and Anisotropic Wood-Derived Composite Scaffold with Antibacterial and Angiogenic Activities for Bone Repair,Advanced Healthcare Materials

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Highly Elastic and Anisotropic Wood-Derived Composite Scaffold with Antibacterial and Angiogenic Activities for Bone Repair
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2023-04-26 , DOI: 10.1002/adhm.202300122
Jiaqing Chen ₁ , Xiangheng He ₁ , Tianyi Sun ₁ , Kun Liu ₁ , Chunhua Chen ₁ , Wei Wen _{1,

2} , Shan Ding _{1,

2} , Mingxian Liu _{1,

2} , Changren Zhou _{1,

2} , Binghong Luo _{1,

2}

Affiliation

Scaffold-based tissue engineering is a promising strategy to address the rapidly growing demand for bone implants, but developing scaffolds with bone extracellular matrix-like structures, suitable mechanical properties, and multiple biological activities remains a huge challenge. Here, it is aimed to develop a wood-derived composite scaffold with an anisotropic porous structure, high elasticity, and good antibacterial, osteogenic, and angiogenic activities. First, natural wood is treated with an alkaline solution to obtain a wood-derived scaffold with an oriented cellulose skeleton and high elasticity, which can not only simulate collagen fiber skeleton in bone tissue but also greatly improve the convenience of clinical implantation. Subsequently, chitosan quaternary ammonium salt (CQS) and dimethyloxalylglycine (DMOG) are further modified on the wood-derived elastic scaffold through a polydopamine layer. Among them, CQS endows the scaffold with good antibacterial activity, while DMOG significantly improves the scaffold's osteogenic and angiogenic activities. Interestingly, the mechanical characteristics of the scaffolds and the modified DMOG can synergistically enhance the expression of yes-associated protein/transcriptional co-activator with PDZ binding motif signaling pathway, thereby effectively promoting osteogenic differentiation. Therefore, this wood-derived composite scaffold is expected to have potential application in the treatment of bone defects.

中文翻译：

用于骨修复的具有抗菌和血管生成活性的高弹性和各向异性木材复合支架

基于支架的组织工程是解决骨植入物快速增长的需求的一种有前途的策略，但开发具有骨细胞外基质样结构、合适的机械性能和多种生物活性的支架仍然是一个巨大的挑战。本研究的目的是开发一种具有各向异性多孔结构、高弹性以及良好抗菌、成骨和血管生成活性的木材复合支架。首先，将天然木材经过碱性溶液处理，得到具有定向纤维素骨架、高弹性的木源支架，不仅可以模拟骨组织中的胶原纤维骨架，而且大大提高了临床植入的便利性。随后，壳聚糖季铵盐（CQS）和二甲基乙二酰甘氨酸（DMOG）通过聚多巴胺层在木材弹性支架上进一步修饰。其中，CQS赋予支架良好的抗菌活性，而DMOG则显着提高支架的成骨和血管生成活性。有趣的是，支架的机械特性和修饰的DMOG可以协同增强yes相关蛋白/转录共激活因子与PDZ结合基序信号通路的表达，从而有效促进成骨分化。因此，这种木质复合支架有望在骨缺损的治疗中具有潜在的应用前景。

更新日期：2023-04-26

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