A Tandem-Locked Fluorescent NETosis Reporter for the Prognosis Assessment of Cancer Immunotherapy,Angewandte Chemie International Edition

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A Tandem-Locked Fluorescent NETosis Reporter for the Prognosis Assessment of Cancer Immunotherapy
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-04-26 , DOI: 10.1002/anie.202301625
Penghui Cheng ₁ , Shasha He ₁ , Chi Zhang ₁ , Jing Liu ₁ , Kanyi Pu _{1,

2}

Affiliation

A tandem-locked NETosis Reporter 1 (TNR₁) is developed for sensitive and specific NETosis detection. TNR₁ activates fluorescence signals only in the presence of both neutrophil elastase and cathepsin G, which are neutrophil granular proteases involved in NETs formation. TNR₁ represents the first sensitive optical reporter for noninvasive monitoring of NETosis levels and evaluation of cancer immunotherapeutic efficacy in tumor-bearing living mice.

中文翻译：

用于癌症免疫治疗预后评估的串联锁定荧光 NETosis 报告基因

串联锁定的 NETosis Reporter 1 (TNR ₁ ) 专为敏感且特异的 NETosis 检测而开发。TNR ₁仅在中性粒细胞弹性蛋白酶和组织蛋白酶 G 均存在的情况下激活荧光信号，这两种酶是参与 NET 形成的中性粒细胞颗粒蛋白酶。TNR ₁代表第一个灵敏的光学报告基因，用于无创监测 NETosis 水平并评估荷瘤活体小鼠的癌症免疫治疗效果。

更新日期：2023-04-26

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