Hierarchical hydrogel scaffolds with a clustered and oriented structure,Journal of Materials Chemistry B

当前位置： X-MOL 学术 › J. Mater. Chem. B › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Hierarchical hydrogel scaffolds with a clustered and oriented structure
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2023-04-26 , DOI: 10.1039/d3tb00497j
Jian Cheng _{1,

2} , Jiangtao Xue _{2,

3} , Yuan Yang ₂ , Dengjie Yu _{2,

4} , Zhuo Liu _{2,

5} , Zhou Li _{1,

2}

Affiliation

Hydrogel scaffolds play a critical role in tissue engineering due to their hydrophilic network structure and good biocompatibility. Constructing anisotropic scaffolds geometrically similar to injured tissues is conducive to promoting the generation of tissue and organ equivalents, or to guiding and enhancing the regeneration of injured tissues. In this study, we developed polyvinyl alcohol (PVA)/alginate hierarchical hydrogel scaffolds with a clustered and oriented structure using a method that combines directional freezing and drying under stretching. Our hydrogel scaffolds with an adjustable modulus (50 kPa–20 MPa) can match different types of injured tissues. The clustered and oriented structure successfully guided the alignment and orientation of fibroblasts and chondrocytes. This work provides a new idea for constructing hydrogels with hierarchical and anisotropic microstructures, which have promising applications in tissue regeneration.

中文翻译：

具有聚集和定向结构的分层水凝胶支架

水凝胶支架由于其亲水网络结构和良好的生物相容性，在组织工程中起着至关重要的作用。构建与损伤组织几何相似的各向异性支架，有利于促进组织器官等同物的生成，或引导和促进损伤组织的再生。在这项研究中，我们使用结合定向冷冻和拉伸干燥的方法开发了具有聚集和定向结构的聚乙烯醇 (PVA)/藻酸盐分级水凝胶支架。我们的水凝胶支架具有可调模量 (50 kPa–20 MPa)，可以匹配不同类型的受伤组织。聚集和定向的结构成功地引导了成纤维细胞和软骨细胞的排列和定向。

更新日期：2023-04-26

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南