The trifluoromethoxy functional group has received increasing attention in recent years due to its distinctive properties such as good metabolic stability, appropriate lipophilicity and special electrical properties. Thus, the development of new reagents and new strategies of direct trifluoromethoxylation are attracting the enthusiasm of many fluorine chemical workers. At present, nucleophilic and radical trifluoromethoxylating reagents have made major breakthroughs, greatly promoting the development of trifluoromethoxy chemistry. This review is mainly divided into two parts: nucleophilic and radical types, focusing on the development history, characteristics and applications of various trifluoromethoxylating reagents.

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三氟甲氧基化试剂的开发及应用

三氟甲氧基官能团近年来因其良好的代谢稳定性、适当的亲油性和特殊的电性能等独特性质而受到越来越多的关注。因此，直接三氟甲氧基化新试剂和新策略的开发吸引了众多氟化工工作者的热情。目前，亲核和自由基三氟甲氧基化试剂已取得重大突破，极大地推动了三氟甲氧基化学的发展。本综述主要分为亲核型和自由基型两部分，重点介绍各种三氟甲氧基化试剂的发展历史、特点和应用。