同时产生 I 型和 II 型 ROS 的 AIE 光敏剂：高效细菌消除和缺氧肿瘤消融,Advanced Functional Materials

当前位置： X-MOL 学术 › Adv. Funct. Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

同时产生 I 型和 II 型 ROS 的 AIE 光敏剂：高效细菌消除和缺氧肿瘤消融
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2023-04-25 , DOI: 10.1002/adfm.202301692
Yuwei Wang ₁ , Jinghan Liao ₂ , Yanting Lyu ₁ , Qianqian Guo ₂ , Zhirong Zhu ₁ , Xupeng Wu ₁ , Jiahong Yu ₁ , Qi Wang ₁ , Wei‐Hong Zhu ₁

Affiliation

聚集诱导发射（AIE）光敏剂因其在光动力治疗（PDT）中的良好表现而受到广泛关注。然而，AIE光敏剂的治疗效果往往高度依赖于生物微环境，因为它很难同时产生I型和II型活性氧（ROS）。在此，富电子阴离子- π ⁺据报道，AIEgen Pys-QM-TT能够高效产生I型和II型ROS，并同步实现近红外荧光成像。在AIE光敏剂的合理设计中，强给电子三苯胺单元、π桥噻吩和吸电子吡啶鎓盐单元可以增强D-π-A行为，从而提高分子内电荷转移效果并延长波长。同时，强大的 D–π–A 效应应该会减少 Δ E _S-T促进系统间交叉过程，从而增加ROS的产生。此外，吡啶鎓盐基团中带负电的阴离子为激发的光敏剂提供富电子环境，从而促进电子转移产生I型ROS。因此，Pys-QM-TT不仅可以同时产生I型和II型ROS，环境依赖性较弱，而且可以通过促进肿瘤细胞凋亡、抑制肿瘤细胞增殖和抗血管生成来有效抑制细菌感染和消融肿瘤组织。

"点击查看英文标题和摘要"

An AIE Photosensitizer with Simultaneous Type I and Type II ROS Generation: Efficient Bacterial Elimination and Hypoxic Tumor Ablation

Aggregation induced emission (AIE) photosensitizers have attracted great attention due to their good performance in photodynamic therapy (PDT). However, the therapeutic effect of AIE photosensitizer is often highly dependent on the biological microenvironment because it is difficult to produce type I and type II reactive oxygen species (ROS) simultaneously. Herein, an electron-rich anion-π⁺ AIEgen Pys-QM-TT is reported, which is capable of highly generating type I and type II ROS and realizing near-infrared fluorescence imaging synchronously. In the rational design of AIE photosensitizer, the strong electron-donating triphenylamine unit, π-bridge thiophene and electron-withdrawing pyridinium salt unit can enhance the D–π–A behavior, thereby improving the intramolecular charge transfer effect and extending the wavelength. Meanwhile, the powerful D–π–A effect is supposed to reduce ∆E_S-T and promote the intersystem crossing processes, thus increasing the generation of ROS. In addition, the negatively charged anion in pyridinium salt group provides an electron-rich environment for the excited photosensitizer, so as to promote electron transfer to generate type I ROS. Therefore, Pys-QM-TT can not only generate type I and type II ROS simultaneously with weak environmental dependence, but also effectively inhibit bacterial infections and ablate tumor tissue by promoting tumor cell apoptosis, inhibiting tumor cell proliferation and anti-angiogenesis.

更新日期：2023-04-25

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南