A highly resourceful synthetic strategy has been developed for the production of spirooxindole derivatives employing Zr-MOF/rGO nanocomposites as a heterogeneous catalyst in aqueous ethanol environments. This protocol involves a three-component one-pot reaction comprising isatin, malononitrile, or ethyl cyanoacetate as well as several 1,3-dicarbonyl compounds at room temperature. In addition to achieving synthetic organic product in the reaction mixture, the produced catalyst could be conveniently collected via centrifugation. This approach has several notable advantages, including the use of green solvents, a short reaction time, operational simplicity, simple reaction conditions, and a high product yield. Furthermore, the resulting Zr-MOF/rGO-nanocatalyst exhibits advantages such as outstanding stability, high activity, and reusability for up to five cycles without significant loss.

已经开发出一种资源丰富的合成策略，用于在含水乙醇环境中使用 Zr-MOF/rGO 纳米复合材料作为多相催化剂生产螺氧吲哚衍生物。该协议涉及三组分一锅反应，包括靛红、丙二腈或氰基乙酸乙酯以及室温下的几种 1,3-二羰基化合物。除了在反应混合物中获得合成有机产物外，还可以通过离心方便地收集产生的催化剂。这种方法有几个显着的优点，包括使用绿色溶剂、反应时间短、操作简单、反应条件简单和产品收率高。此外，所得 Zr-MOF/rGO 纳米催化剂具有稳定性好、活性高、