<br>生物医用镁合金植入物复合纳米涂层：优势、机制和设计策略,Advanced Science

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生物医用镁合金植入物复合纳米涂层：优势、机制和设计策略
Advanced Science ( IF 14.3 ) Pub Date : 2023-04-25 , DOI: 10.1002/advs.202300658
Dan Li ₁ , Danni Dai ₁ , Gege Xiong ₁ , Shuquan Lan ₁ , Chao Zhang ₁

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镁合金植入物的快速降解会侵蚀机械性能和界面生物活性，从而限制其临床应用。表面改性是提高镁合金耐腐蚀性和生物功效的解决方案之一。包含纳米结构的新型复合涂层为其扩大用途创造了新的机会。粒径优势和不渗透性可以提高耐腐蚀性，从而延长植入物的使用寿命。具有特定生物效应的纳米颗粒可能会在涂层降解过程中释放到种植体周围微环境中，以促进愈合。复合纳米涂层提供纳米级表面以促进细胞粘附和增殖。纳米颗粒可以激活细胞信号传导途径，而具有多孔或核壳结构的纳米颗粒可以携带抗菌或免疫调节药物。复合纳米涂层可以促进血管再内皮化和成骨、减轻炎症并抑制细菌生长，从而增加其在动脉粥样硬化和开放性骨折等复杂临床微环境中的适用性。本文结合镁基合金生物医用植入物的理化性能和生物效率，总结复合纳米涂层的优点，分析其作用机制，并提出设计和构建策略，旨在为促进镁基合金生物医用植入物的临床应用提供参考。镁合金植入物并进一步设计纳米涂层。

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Composite Nanocoatings of Biomedical Magnesium Alloy Implants: Advantages, Mechanisms, and Design Strategies

The rapid degradation of magnesium (Mg) alloy implants erodes mechanical performance and interfacial bioactivity, thereby limiting their clinical utility. Surface modification is among the solutions to improve corrosion resistance and bioefficacy of Mg alloys. Novel composite coatings that incorporate nanostructures create new opportunities for their expanded use. Particle size dominance and impermeability may increase corrosion resistance and thereby prolong implant service time. Nanoparticles with specific biological effects may be released into the peri-implant microenvironment during the degradation of coatings to promote healing. Composite nanocoatings provide nanoscale surfaces to promote cell adhesion and proliferation. Nanoparticles may activate cellular signaling pathways, while those with porous or core–shell structures may carry antibacterial or immunomodulatory drugs. Composite nanocoatings may promote vascular reendothelialization and osteogenesis, attenuate inflammation, and inhibit bacterial growth, thus increasing their applicability in complex clinical microenvironments such as those of atherosclerosis and open fractures. This review combines the physicochemical properties and biological efficiency of Mg-based alloy biomedical implants to summarize the advantages of composite nanocoatings, analyzes their mechanisms of action, and proposes design and construction strategies, with the purpose of providing a reference for promoting the clinical application of Mg alloy implants and to further the design of nanocoatings.

更新日期：2023-04-25

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