Preparation of UFM1-Derived Probes through Highly Optimized Total Chemical Synthesis**,Chemistry - A European Journal

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Preparation of UFM1-Derived Probes through Highly Optimized Total Chemical Synthesis**
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2023-04-20 , DOI: 10.1002/chem.202300414
Cong Chen ₁ , Chengpiao Lu ₁ , Fang Li ₁ , Haibo Wang ₁ , Shuai Peng ₁ , Guoqiang Xu ₁ , Hongrui Xu ₂ , Jia-Bin Li ₁

Affiliation

A total chemical synthesis strategy utilizing UFM1 C-terminal valine hydrazide as a versatile handle is reported for the facile preparation of UFM1-derived probes. This approach allows the convenient installation of electrophilic warheads, fluorescent reporters and unnatural purification tags onto the UFM1 sequence.

中文翻译：