Cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS) detects infections or tissue damage by binding to microbial or self-DNA in the cytoplasm. Upon binding DNA, cGAS produces cGAMP that binds to and activates the adaptor protein stimulator of interferon genes (STING), which then activates the kinases IKK and TBK1 to induce the secretion of interferons and other cytokines. Recently, a series of studies demonstrated that the cGAS-STING pathway, a vital component of host innate immunity, might play an important role in anticancer immunity, though its mechanism remains to be elucidated. In this review, we highlight the latest understanding of the cGAS-STING pathway in tumor development and the advances in combination therapy of STING agonists and immunotherapy.

中文翻译：

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干扰素基因通路的环磷酸鸟苷合酶刺激剂作为肿瘤免疫治疗的潜在靶点

环磷酸鸟苷-磷酸腺苷 (cGAMP) 合酶 (cGAS) 通过与细胞质中的微生物或自身 DNA 结合来检测感染或组织损伤。结合 DNA 后，cGAS 产生 cGAMP，它结合并激活干扰素基因的衔接蛋白刺激物 (STING)，然后激活激酶 IKK 和 TBK1 以诱导干扰素和其他细胞因子的分泌。最近，一系列研究表明，cGAS-STING通路是宿主先天免疫的重要组成部分，可能在抗癌免疫中发挥重要作用，但其机制仍有待阐明。在这篇综述中，我们重点介绍了对肿瘤发展中的 cGAS-STING 通路的最新认识，以及 STING 激动剂和免疫疗法联合治疗的进展。