Perspective on the Effect of Membrane Mimetics on Dynamic Properties of Integral Membrane Proteins,The Journal of Physical Chemistry B

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Perspective on the Effect of Membrane Mimetics on Dynamic Properties of Integral Membrane Proteins
The Journal of Physical Chemistry B ( IF 2.8 ) Pub Date : 2023-04-20 , DOI: 10.1021/acs.jpcb.2c07324
Indra D Sahu _{1,

2} , Gary A Lorigan ₂

Affiliation

Integral membrane proteins are embedded into cell membranes by spanning the width of the lipid bilayer. They play an essential role in important biological functions for the survival of living organisms. Their functions include the transportation of ions and molecules across the cell membrane and initiating signaling pathways. The dynamic behavior of integral membrane proteins is very important for their function. Due to the complex behavior of integral membrane proteins in the cell membrane, studying their structural dynamics using biophysical approaches is challenging. Here, we concisely discuss challenges and recent advances in technical and methodological aspects of biophysical approaches for gleaning dynamic properties of integral membrane proteins to answer pertinent biological questions associated with these proteins.

中文翻译：

膜模拟物对整合膜蛋白动态特性影响的观点

整合膜蛋白通过跨越脂质双层的宽度嵌入细胞膜中。它们在生物体生存的重要生物学功能中起着至关重要的作用。它们的功能包括离子和分子穿过细胞膜的运输和启动信号通路。整合膜蛋白的动态行为对其功能非常重要。由于整合膜蛋白在细胞膜中的复杂行为，使用生物物理方法研究其结构动力学具有挑战性。在这里，我们简明扼要地讨论了生物物理方法在技术和方法方面的挑战和最新进展，这些方法用于收集整合膜蛋白的动态特性，以回答与这些蛋白质相关的生物学问题。

更新日期：2023-04-20

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