Practical synthetic methods for biogenetically and pharmaceutically important phytofluene were developed through the divergent preparation of key C₂₀ substrates from a common intermediate and convergent synthesis by Wittig and Julia–Kocienski olefinations. Expeditious synthesis of phytofluene was also proposed based on the Julia sulfone-mediated chain-extension and double elimination method. Stereochemical outcomes of these olefination methods for phytofluene were compared and the Julia–Kocienski method was the mildest and most efficient reaction condition to produce all-(E)-phytofluene. Complete ¹H and ¹³C NMR analysis of all-(E)-phytofluene is reported for the first time. Phytofluene undergoes facile thermal isomerization to other Z-isomers above room temperature, which was also confirmed with a C₃₀ phytofluene homologue.

生物遗传学和药学上重要的植物氟烯的实用合成方法是通过从普通中间体中分离制备关键的 C _{20底物以及通过 Wittig 和 Julia–Kocienski 烯烃化聚合合成而开发的。}还提出了基于 Julia 砜介导的扩链和双消除法快速合成植物氟烯。比较了这些植物氟烯化方法的立体化学结果，Julia–Kocienski 方法是生产全 ( E )-植物氟烯的最温和、最有效的反应条件。完成所有-( E的¹ H 和¹³ C NMR 分析)-phytofluene 为首次报道。植物氟在室温以上容易热异构化为其他Z异构体，这也用 C ₃₀植物氟同系物证实。