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Divergent access to fused N-heterocycle-thiazolines by solvent-dependent reaction of isoquinolinium thiolates with silylketene acetals
Chemical Communications ( IF 4.3 ) Pub Date : 2023-04-19 , DOI: 10.1039/d3cc00781b Lukas Schifferer 1 , Leon Hoppmann 1 , Robin Groeters 1 , Christian Mück-Lichtenfeld 1 , Constantin G Daniliuc 1 , Olga García Mancheño 1
Chemical Communications ( IF 4.3 ) Pub Date : 2023-04-19 , DOI: 10.1039/d3cc00781b Lukas Schifferer 1 , Leon Hoppmann 1 , Robin Groeters 1 , Christian Mück-Lichtenfeld 1 , Constantin G Daniliuc 1 , Olga García Mancheño 1
Affiliation
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A solvent-dependent, divergent synthesis of highly functionalized N,S-heterocycles presenting a thiazoline and an isoquinuclidine (DCE as solvent) or tetrahydroisoquinoline (DMF as solvent) scaffolds by cyclization reactions of isoquinolinium 1,4-zwitterionic thiolates is reported. The robustness and applicability of the method are also demonstrated by an efficient 6-times upscaling of the reaction and derivatization of the thiazoline–isoquinuclidine derivatives.
中文翻译：
异喹啉硫醇盐与甲硅烷基烯酮缩醛的溶剂依赖性反应对稠合 N-杂环-噻唑啉的分离途径
报道了通过异喹啉 1,4-两性离子硫醇盐的环化反应，呈递噻唑啉和异奎宁环（DCE 作为溶剂）或四氢异喹啉（DMF 作为溶剂）支架的高功能化 N、S 杂环的溶剂依赖性发散合成。该方法的稳健性和适用性也通过噻唑啉-异奎宁环衍生物的反应和衍生化的有效 6 倍放大得到证明。
更新日期：2023-04-19
中文翻译：
异喹啉硫醇盐与甲硅烷基烯酮缩醛的溶剂依赖性反应对稠合 N-杂环-噻唑啉的分离途径
报道了通过异喹啉 1,4-两性离子硫醇盐的环化反应，呈递噻唑啉和异奎宁环（DCE 作为溶剂）或四氢异喹啉（DMF 作为溶剂）支架的高功能化 N、S 杂环的溶剂依赖性发散合成。该方法的稳健性和适用性也通过噻唑啉-异奎宁环衍生物的反应和衍生化的有效 6 倍放大得到证明。
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