Asymmetric Synthesis of Chiral Seven-Membered NHCs, Their Transition-Metal Complexes and Application in Asymmetric Catalysis,Synthesis

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Asymmetric Synthesis of Chiral Seven-Membered NHCs, Their Transition-Metal Complexes and Application in Asymmetric Catalysis
Synthesis ( IF 2.2 ) Pub Date : 2023-04-17 , DOI: 10.1055/s-0042-1751439
Jiahong Han _{1,

2} , Yixiao Pan ₁ , Wei Hao ₁ , Qing-Hua Fan _{1,

2}

Affiliation

A series of new chiral seven-membered NHCs were synthesized via Ru-catalyzed asymmetric hydrogenation reactions as the key step. Transition metal such as Rh, Ir and Au can coordinate to the developed NHCs. The crystal structures of the chiral seven-membered NHCs and their transition-metal complexes show a nonplanar framework with torsional twist. Furthermore, the chiral NHCs were applied in asymmetric hydrosilylation reactions, and the corresponding product was obtained with >95% yield and up to 83% ee.

中文翻译：

手性七元NHC的不对称合成、过渡金属配合物及其在不对称催化中的应用

以Ru催化的不对称氢化反应为关键步骤，合成了一系列新型手性七元NHCs。Rh、Ir 和 Au 等过渡金属可以与发达的 NHC 配位。手性七元 NHC 及其过渡金属配合物的晶体结构显示出具有扭转扭曲的非平面框架。此外，手性NHC应用于不对称氢化硅烷化反应，并以>95%的收率和高达83%的ee获得相应的产物。

更新日期：2023-04-18

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