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Nanoarchitecture-Integrated Hydrogel Systems toward Therapeutic Applications
ACS Nano ( IF 15.8 ) Pub Date : 2023-04-18 , DOI: 10.1021/acsnano.2c12448 Houjuan Zhu 1 , Jie Zheng 2 , Xin Yi Oh 1 , Chui Yu Chan 1 , Beverly Qian Ling Low 1 , Jia Qian Tor 1 , Wenbin Jiang 1 , Enyi Ye 1, 2 , Xian Jun Loh 1, 2 , Zibiao Li 1, 2, 3
ACS Nano ( IF 15.8 ) Pub Date : 2023-04-18 , DOI: 10.1021/acsnano.2c12448 Houjuan Zhu 1 , Jie Zheng 2 , Xin Yi Oh 1 , Chui Yu Chan 1 , Beverly Qian Ling Low 1 , Jia Qian Tor 1 , Wenbin Jiang 1 , Enyi Ye 1, 2 , Xian Jun Loh 1, 2 , Zibiao Li 1, 2, 3
Affiliation
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Hydrogels, as one of the most feasible soft biomaterials, have gained considerable attention in therapeutic applications by virtue of their tunable properties including superior patient compliance, good biocompatibility and biodegradation, and high cargo-loading efficiency. However, hydrogel application is still limited by some challenges like inefficient encapsulation, easy leakage of loaded cargoes, and the lack of controllability. Recently, nanoarchitecture-integrated hydrogel systems were found to be therapeutics with optimized properties, extending their bioapplication. In this review, we briefly presented the category of hydrogels according to their synthetic materials and further discussed the advantages in bioapplication. Additionally, various applications of nanoarchitecture hybrid hydrogels in biomedical engineering are systematically summarized, including cancer therapy, wound healing, cardiac repair, bone regeneration, diabetes therapy, and obesity therapy. Last, the current challenges, limitations, and future perspectives in the future development of nanoarchitecture-integrated flexible hydrogels are addressed.
中文翻译：
面向治疗应用的纳米结构集成水凝胶系统
水凝胶作为最可行的软生物材料之一，凭借其可调节的特性（包括出色的患者依从性、良好的生物相容性和生物降解性以及高载货效率）在治疗应用中获得了相当大的关注。然而，水凝胶的应用仍然受到一些挑战的限制，例如封装效率低下、装载货物容易泄漏以及缺乏可控性。最近，发现纳米结构集成水凝胶系统是具有优化特性的治疗方法，扩展了它们的生物应用。在这篇综述中，我们根据合成材料简要介绍了水凝胶的类别，并进一步讨论了其在生物应用中的优势。此外，系统总结了纳米结构杂化水凝胶在生物医学工程中的各种应用，包括癌症治疗、伤口愈合、心脏修复、骨再生、糖尿病治疗和肥胖治疗。最后，讨论了纳米结构集成柔性水凝胶未来发展中的当前挑战、局限性和未来前景。
更新日期：2023-04-18
中文翻译：
面向治疗应用的纳米结构集成水凝胶系统
水凝胶作为最可行的软生物材料之一，凭借其可调节的特性（包括出色的患者依从性、良好的生物相容性和生物降解性以及高载货效率）在治疗应用中获得了相当大的关注。然而，水凝胶的应用仍然受到一些挑战的限制，例如封装效率低下、装载货物容易泄漏以及缺乏可控性。最近，发现纳米结构集成水凝胶系统是具有优化特性的治疗方法，扩展了它们的生物应用。在这篇综述中，我们根据合成材料简要介绍了水凝胶的类别，并进一步讨论了其在生物应用中的优势。此外，系统总结了纳米结构杂化水凝胶在生物医学工程中的各种应用，包括癌症治疗、伤口愈合、心脏修复、骨再生、糖尿病治疗和肥胖治疗。最后，讨论了纳米结构集成柔性水凝胶未来发展中的当前挑战、局限性和未来前景。
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