Transethosomes：透皮给药系统中增强药物渗透的前沿方法,Chemical Biology & Drug Design

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Transethosomes：透皮给药系统中增强药物渗透的前沿方法
Chemical Biology & Drug Design ( IF 3.2 ) Pub Date : 2023-04-16 , DOI: 10.1111/cbdd.14254
Bhabani Shankar Nayak ₁ , Biswaranjan Mohanty ₁ , Bibaswan Mishra ₁ , Harekrishna Roy ₂ , Sisir Nandi ₃

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皮肤是给药的主要途径。尽管皮肤表面积很大，但由于其生理障碍，通过皮肤途径的药物输送仍然存在问题。配方科学家开发了一种囊泡系统，可以增强皮肤对生物活性物质的吸收。在众多的囊泡系统中，2012 年推出的转质体 (TE) 概念正在测试用于将药物输送到真皮。当转移体和乙醇体相互作用时，就会产生 TE。它由水、乙醇、磷脂和边缘激活剂组成。乙醇和边缘活化剂可增加皮肤对药物的吸收。在乙醇和边缘活化剂存在下，皮肤渗透性会增加。TE 的优点包括提高患者依从性、绕过首过代谢、包括无毒原料成分、作为一种非侵入性药物输送方法、更稳定、生物相容性、可生物降解以及以半固体形式给药。TE 可以通过使用热分散、冷分散、机械分散和传统技术来生产。TE 的形态、形状、大小、zeta 电位、载药效率、囊泡产量、生物物理相互作用和稳定性定义了它们。最近的研究报道了抗真菌、抗病毒、抗炎和心血管生物活性物质的成功透皮分布，同时使用了对皮肤具有显着更深渗透性的醇质体。该评论广泛讨论了研究人员开发的 TE、专利和市售乙醇的各种主张。然而，直到今天还没有授予 TE 专利。与基于乙醇的 TE 相关的困难仍然存在，需要大量研究来解决。

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Transethosomes: Cutting edge approach for drug permeation enhancement in transdermal drug delivery system

The skin is a major route of drug administration. Despite the high surface area of the skin, drug delivery via the skin route is problematic due to its physiological obstacles. The formulation scientist has developed a vesicular system to enhance the skin's absorption of bioactive substances. Among numerous vesicular systems, concept of transethosomes (TEs) introduced in 2012 are being tested for drug delivery to the dermis. When transferosomes and ethosomes interact, TEs are produced. It consists of water, ethanol, phospholipids, and an edge activator. Ethanol and the edge activator increase the absorption of medication through the skin. In the presence of ethanol and an edge activator, skin permeability can increase. The advantages of TEs include increased patient compliance, bypassing first-pass metabolism, including non-toxic raw components, being a noninvasive method of drug delivery, being more stable, biocompatible, biodegradable, and administered in semisolid form. TEs can be produced through the use of hot, cold, mechanical dispersion, and conventional techniques. The morphology, shape, size, zeta potential, drug loading efficiency, vesicle yield, biophysical interactions, and stability of TEs define them. Recent studies reported successful transdermal distribution of antifungal, antiviral, anti-inflammatory, and cardiovascular bioactive while using ethosomes with significant deeper penetration in skin. The review extensively discussed various claims on TEs developed by researchers, patents, and marketed ethosomes. However, till today no patens being granted on TEs. There are still lingering difficulties related to ethanol-based TEs that require substantial research to fix.

更新日期：2023-04-16

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