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A Porphyrin‐Based Conjugated Polymer for Highly Efficient In Vitro and In Vivo Photothermal Therapy
Small ( IF 13.0 ) Pub Date : 2016-09-27 , DOI: 10.1002/smll.201602293 Bing Guo 1 , Guangxue Feng 1 , Purnima Naresh Manghnani 1 , Xiaolei Cai 1 , Jie Liu 1 , Wenbo Wu 1 , Shidang Xu 1 , Xiamin Cheng 1 , Cathleen Teh 2 , Bin Liu 1, 3
Small ( IF 13.0 ) Pub Date : 2016-09-27 , DOI: 10.1002/smll.201602293 Bing Guo 1 , Guangxue Feng 1 , Purnima Naresh Manghnani 1 , Xiaolei Cai 1 , Jie Liu 1 , Wenbo Wu 1 , Shidang Xu 1 , Xiamin Cheng 1 , Cathleen Teh 2 , Bin Liu 1, 3
Affiliation
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Conjugated polymers have been increasingly studied for photothermal therapy (PTT) because of their merits including large absorption coefficient, facile tuning of exciton energy dissipation through nonradiative decay, and good therapeutic efficacy. The high photothermal conversion efficiency (PCE) is the key to realize efficient PTT. Herein, a donor–acceptor (D–A) structured porphyrin‐containing conjugated polymer (PorCP) is reported for efficient PTT in vitro and in vivo. The D–A structure introduces intramolecular charge transfer along the backbone, resulting in redshifted Q band, broadened absorption, and increased extinction coefficient as compared to the state‐of‐art porphyrin‐based photothermal reagent. Through nanoencapsulation, the dense packing of a large number of PorCP molecules in a single nanoparticle (NP) leads to favorable nonradiative decay, good photostability, and high extinction coefficient of 4.23 × 104m−1 cm−1 at 800 nm based on porphyrin molar concentration and the highest PCE of 63.8% among conjugated polymer NPs. With the aid of coloaded fluorescent conjugated polymer, the cellular uptake and distribution of the PorCP in vitro can be clearly visualized, which also shows effective photothermal tumor ablation in vitro and in vivo. This research indicates a new design route of conjugated polymer‐based photothermal therapeutic materials for potential personalized theranostic nanomedicine.
中文翻译：
一种基于卟啉的共轭聚合物，用于高效的体内和体外光热疗法
由于共轭聚合物的优点包括吸收系数大，通过非辐射衰减容易调节激子能量耗散以及良好的治疗功效，因此越来越多地研究了共轭聚合物用于光热疗法（PTT）。高光热转换效率（PCE）是实现高效PTT的关键。本文报道了一种供体-受体（D-A）结构的含卟啉共轭聚合物（PorCP），可用于体外和体内有效的PTT。与最先进的基于卟啉的光热试剂相比，D–A结构沿主链引入了分子内电荷转移，导致Q谱带发生红移，吸收变宽以及消光系数增加。通过纳米封装，在800 nm处基于卟啉摩尔浓度为4 m -1 cm -1，在共轭聚合物NP中的最高PCE为63.8％。借助于共装载的荧光共轭聚合物，可以清楚地观察到PorCP在体外的细胞摄取和分布，这也显示了在体外和体内有效的光热肿瘤消融。这项研究表明了基于共轭聚合物的光热治疗材料的新设计路线，可用于潜在的个性化治疗学纳米药物。
更新日期：2016-09-27
中文翻译：
一种基于卟啉的共轭聚合物，用于高效的体内和体外光热疗法
由于共轭聚合物的优点包括吸收系数大，通过非辐射衰减容易调节激子能量耗散以及良好的治疗功效，因此越来越多地研究了共轭聚合物用于光热疗法（PTT）。高光热转换效率（PCE）是实现高效PTT的关键。本文报道了一种供体-受体（D-A）结构的含卟啉共轭聚合物（PorCP），可用于体外和体内有效的PTT。与最先进的基于卟啉的光热试剂相比，D–A结构沿主链引入了分子内电荷转移，导致Q谱带发生红移，吸收变宽以及消光系数增加。通过纳米封装，在800 nm处基于卟啉摩尔浓度为4 m -1 cm -1，在共轭聚合物NP中的最高PCE为63.8％。借助于共装载的荧光共轭聚合物，可以清楚地观察到PorCP在体外的细胞摄取和分布，这也显示了在体外和体内有效的光热肿瘤消融。这项研究表明了基于共轭聚合物的光热治疗材料的新设计路线，可用于潜在的个性化治疗学纳米药物。
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