The Fenton reaction refers to the decomposition of hydrogen peroxide catalyzed by ferrous ions (Fe) to generate hydroxyl radicals (·OH). Due to the strong oxidizing capacities of ·OH, the Fenton reaction is widely used in the treatment of refractory organic pollutants and chemodynamic therapy (CDT). However, the traditional Fenton reaction has various limitations, for example, the optimum operation pH value is about 3, and the reaction rate is limited by the lack of the Fenton reagent. Therefore, the nanomaterial-modulated Fenton (NMM-Fenton) reaction has been extensively studied to improve the efficiency of the Fenton reaction. In this review, the mechanisms and strategies of the NMM-Fenton reaction are systematically reviewed, including the conventional Fenton reaction and the external energy input Fenton reaction. First, the process of the Fenton reaction is briefly introduced, including the Fenton reaction and Fenton-like reaction. Then, the enhancement mechanism of nanomaterials on the NMM-Fenton and the construction of the NMM-Fenton strategy are discussed, and their biological applications are summarized in detail. Finally, the challenges and future directions of NMM-Fenton and NMM-Fenton-based applications in CDT are described. It is believed that this paper is of great significance to the design and construction of the Fenton reaction.

中文翻译：

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纳米材料调节芬顿反应：策略、化学动力学疗法和未来趋势

芬顿反应是指过氧化氢在亚铁离子（Fe）的催化下分解生成羟基自由基（·OH）。由于·OH的强氧化能力，芬顿反应广泛应用于难降解有机污染物的处理和化学动力学疗法（CDT）。然而，传统的Fenton反应存在各种局限性，例如，最佳操作pH值约为3，且由于缺少Fenton试剂，反应速率受到限制。因此，纳米材料调制的芬顿（NMM-Fenton）反应得到了广泛的研究，以提高芬顿反应的效率。本文对NMM-Fenton反应的机理和策略进行了系统综述，包括常规Fenton反应和外部能量输入Fenton反应。首先简要介绍芬顿反应的过程，包括芬顿反应和类芬顿反应。然后讨论了纳米材料对NMM-Fenton的增强机制以及NMM-Fenton策略的构建，并详细总结了其生物学应用。最后，描述了 NMM-Fenton 和基于 NMM-Fenton 的 CDT 应用的挑战和未来方向。相信本文对于Fenton反应的设计和构建具有重要意义。