Oxygen-Vacancy-Rich Piezoelectric BiO2−x Nanosheets for Augmented Piezocatalytic, Sonothermal, and Enzymatic Therapies,Advanced Materials

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Oxygen-Vacancy-Rich Piezoelectric BiO2−x Nanosheets for Augmented Piezocatalytic, Sonothermal, and Enzymatic Therapies
Advanced Materials ( IF 27.4 ) Pub Date : 2023-04-14 , DOI: 10.1002/adma.202300648
Lu Yang _{1,

2} , Boshi Tian ₁ , Ying Xie ₃ , Shuming Dong ₁ , Meiqi Yang ₁ , Shili Gai ₁ , Jun Lin ₂

Affiliation

Piezocatalytic therapy is a new-emerging reactive oxygen species (ROS)-enabled therapeutic strategy that relies on built-in electric field and energy-band bending of piezoelectric materials activated by ultrasound (US) irradiation. Despite becoming a hot topic, material development and mechanism exploration are still underway. Herein, as-synthesized oxygen-vacancy-rich BiO₂₋_x nanosheets (NSs) demonstrate outstanding piezoelectric properties. Under US, a piezo-potential of 0.25 V for BiO₂₋_x NSs is sufficient to tilt the conduction band to be more negative than the redox potentials of O₂/^•O₂⁻, ^•O₂⁻/H₂O₂, and H₂O₂/^•OH, which initiates a cascade reaction for ROS generation. Moreover, the BiO₂₋_x NSs exhibit peroxidase and oxidase-like activities to augment ROS production, especially in the H₂O₂-overexpressed tumor microenvironment. Density functional theory calculations show that the generated oxygen vacancies in BiO₂₋_x NSs are favorable for H₂O₂ adsorption and increasing the carrier density to produce ROS. Furthermore, the quick movement of electrons enables an excellent sonothermal effect, for example, rapid rise in temperature to nearly 65 °C upon US with low power (1.2 W cm⁻²) and short time (96 s). Therefore, this system realizes a multimode synergistic combination of piezocatalytic, enzymatic, and sonothermal therapies, providing a new direction for defect engineering-optimized piezoelectric materials for tumor therapy.

中文翻译：

用于增强压电催化、声热和酶疗法的富氧空位压电 BiO2−x 纳米片

压电催化疗法是一种新兴的活性氧（ROS）驱动的治疗策略，依赖于超声（US）辐射激活的压电材料的内置电场和能带弯曲。尽管成为热门话题，材料开发和机制探索仍在进行中。在此，合成的富含氧空位的BiO ₂₋_x纳米片（NSs）表现出出色的压电性能。_{在 US 下，BiO 2−}_x NS的 0.25 V 压电势足以使导带倾斜得比 O ₂ / ^• O ₂⁻、^• O ₂⁻ /H ₂ O ₂的氧化还原电位更负，和H ₂ O ₂ / ^• OH，引发ROS 生成的级联反应。此外，BiO ₂₋_x NSs 表现出过氧化物酶和氧化酶样活性，可增加 ROS 的产生，特别是在 H ₂ O ₂过表达的肿瘤微环境中。密度泛函理论计算表明，BiO ₂₋_x NSs 中产生的氧空位有利于 H ₂ O ₂ 吸附并增加载流子密度以产生 ROS。此外，电子的快速运动实现了优异的声热效应，例如，在低功率（1.2 W cm -2 ）和短时间（96 s）的超声下温度快速升高至近65 ° ^C。因此，该系统实现了压电催化、酶促和声热疗法的多模式协同组合，为缺陷工程优化的压电材料用于肿瘤治疗提供了新的方向。

更新日期：2023-04-14

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