As a signal molecule, SO₂ plays an important role in the process of cell metabolism. The abnormal level of sulfur dioxide will induce many diseases of human body. Viscosity is an important index of lysosome. Abnormal lysosome viscosity can also lead to many diseases. Therefore, we have developed a new fluorescence probe PAPD for simultaneous imaging of sulfur dioxide derivatives and lysosomal viscosity. The probe realizes rapid detection of HSO₃⁻ based on Michael addition reaction mechanism. At the same time, with the increase of viscosity, intramolecular rotation is inhibited, thus the probe shows sensitive fluorescence enhancement. In addition, the results of the co-localization experiments show that PAPD has good lysosomal targeting ability. Further studies show that PAPD can be used as a dual-responsive fluorescence probe for SO₂ and viscosity in lysosomes.

_{SO 2}作为信号分子，在细胞代谢过程中起着重要作用。二氧化硫含量异常会诱发人体多种疾病。粘度是溶酶体的一个重要指标。异常的溶酶体粘度也会导致许多疾病。因此，我们开发了一种新的荧光探针 PAPD，用于二氧化硫衍生物和溶酶体粘度的同时成像。_{该探针实现了对HSO 3} ⁻的快速检测基于迈克尔加成反应机理。同时，随着粘度的增加，分子内旋转受到抑制，探针显示出灵敏的荧光增强。此外，共定位实验结果表明PAPD具有良好的溶酶体靶向能力。进一步的研究表明，PAPD 可用作溶酶体中SO _{2和粘度的双响应荧光探针。}