Single Atom-Engineered NIR-II Gold Clusters with Ultrahigh Brightness and Stability for Acute Kidney Injury,Small

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Single Atom-Engineered NIR-II Gold Clusters with Ultrahigh Brightness and Stability for Acute Kidney Injury
Small ( IF 13.0 ) Pub Date : 2023-04-14 , DOI: 10.1002/smll.202300145
You Huang ₁ , Ke Chen ₁ , Ling Liu ₁ , Huizhen Ma ₂ , Xiaoning Zhang ₁ , Kexin Tan ₁ , Yuan Li ₂ , Ying Liu ₂ , Changlong Liu ₂ , Hao Wang ₁ , Xiao-Dong Zhang ₁

Affiliation

Near-infrared-II (NIR-II) imaging has shown great potential for monitoring the pathological progression and deep tissue imaging but is limited to present unmet NIR-II agent. Present fluorophores show a promising prospect for NIR-II imaging, but brightness and photostability are still highly challenging during real-time monitoring. In this work, atom-engineered NIR-II Au₂₄Cd₁ clusters with ultrahigh brightness, stability, and photostability are developed via single atomic Cd doping. Single atom Cd substitutions contribute to Cd 4d state in HOMO and redistribution of energy level near the gap, exhibiting 56-fold fluorescence enhancement of Au₂₄Cd₁ clusters. Meanwhile, single atomic Cd reinforces CdAu bond energy, formation energy, and stabilized cluster structure, leading to persistent stability for up to 1 month without decay, as well as excellent photostability of 1 h without photobleaching, much longer than clinically approved indocyanine green (<5 min). In vivo imaging shows gold clusters can monitor acute kidney injury (AKI) even after 72 h of injury, enabling evaluating progression at a very long window. Meanwhile, the bioactive gold clusters can alleviate AKI-induced oxidative stress damage and acute neuroinflammation. Single atom-engineered gold clusters exhibit molecular tracking and diagnostic prospect in kidney-related diseases.

中文翻译：

单原子工程 NIR-II 金簇，具有超高亮度和稳定性，可治疗急性肾损伤

近红外 II (NIR-II) 成像在监测病理进展和深部组织成像方面显示出巨大潜力，但仅限于目前未满足的 NIR-II 试剂。目前的荧光团在 NIR-II 成像方面显示出广阔的前景，但在实时监测过程中，亮度和光稳定性仍然面临很大的挑战。在这项工作中，通过单原子 Cd 掺杂开发了具有超高亮度、稳定性和光稳定性的原子工程 NIR-II Au ₂₄ Cd _1团簇。_{单原子 Cd 取代有助于 HOMO 中的 Cd 4d 态以及能隙附近能级的重新分布，使 Au 24} Cd ₁ 团簇的荧光增强了 56 倍。同时，单原子Cd增强了CdAu键能、形成能和稳定的簇结构，导致长达1个月的持续稳定性而不衰减，以及1小时不光漂白的优异光稳定性，远长于临床批准的吲哚菁绿（<5 分钟）。体内成像显示，即使在损伤 72 小时后，金簇也可以监测急性肾损伤 (AKI)，从而能够在很长的窗口内评估进展情况。同时，具有生物活性的金簇可以减轻AKI引起的氧化应激损伤和急性神经炎症。单原子工程金簇在肾脏相关疾病中展现出分子追踪和诊断前景。

更新日期：2023-04-14

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