Engineering Single-Atom Nanozymes for Catalytic Biomedical Applications,Small

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Engineering Single-Atom Nanozymes for Catalytic Biomedical Applications
Small ( IF 13.0 ) Pub Date : 2023-04-14 , DOI: 10.1002/smll.202300750
Yang Zhu _{1,

2,

3,

4,

5} , Yaxin Liao ₁ , Jianhua Zou _{2,

3,

4,

5} , Junjie Cheng ₆ , Yuanbo Pan _{2,

3,

4,

5} , Lisen Lin ₁ , Xiaoyuan Chen _{2,

3,

4,

5}

Affiliation

Nanomaterials with enzyme-mimicking properties, coined as nanozymes, are a promising alternative to natural enzymes owing to their remarkable advantages, such as high stability, easy preparation, and favorable catalytic performance. Recently, with the rapid development of nanotechnology and characterization techniques, single atom nanozymes (SAzymes) with atomically dispersed active sites, well-defined electronic and geometric structures, tunable coordination environment, and maximum metal atom utilization are developed and exploited. With superior catalytic performance and selectivity, SAzymes have made impressive progress in biomedical applications and are expected to bridge the gap between artificial nanozymes and natural enzymes. Herein, the recent advances in SAzyme preparation methods, catalytic mechanisms, and biomedical applications are systematically summarized. Their biomedical applications in cancer therapy, oxidative stress cytoprotection, antibacterial therapy, and biosensing are discussed in depth. Furthermore, to appreciate these advances, the main challenges, and prospects for the future development of SAzymes are also outlined and highlighted in this review.

中文翻译：

用于催化生物医学应用的单原子纳米酶工程

具有模仿酶特性的纳米材料（被称为纳米酶）因其稳定性高、易于制备和良好的催化性能等显着优点而成为天然酶的有前途的替代品。近年来，随着纳米技术和表征技术的快速发展，具有原子分散的活性位点、明确的电子和几何结构、可调节的配位环境和最大金属原子利用率的单原子纳米酶（SAzymes）被开发和利用。凭借卓越的催化性能和选择性，SAzymes 在生物医学应用中取得了令人瞩目的进展，有望弥补人工纳米酶和天然酶之间的差距。本文系统总结了SAzyme的制备方法、催化机制和生物医学应用的最新进展。深入讨论了它们在癌症治疗、氧化应激细胞保护、抗菌治疗和生物传感方面的生物医学应用。此外，为了理解这些进展，本综述还概述并强调了 SAzymes 未来发展的主要挑战和前景。

更新日期：2023-04-14

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