Synthesis of Ledipasvir through a Late-Stage Cyclopropanation and Fluorination Process,Synthesis

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Synthesis of Ledipasvir through a Late-Stage Cyclopropanation and Fluorination Process
Synthesis ( IF 2.2 ) Pub Date : 2023-04-13 , DOI: 10.1055/s-0042-1751437
Gangarajula Sudhakar _{1,

2} , Chennam Ramu _{1,

2} , T. Kumaraguru _{1,

2} , M. Sridhar Reddy _{1,

2} , Haridas B. Rode _{1,

2} , Subhash Ghosh _{1,

2} , Ch. Raji Reddy _{1,

2}

Affiliation

We have designed and developed an easily accessible advanced intermediate of ledipasvir that allowed late-stage cyclopropanation and difluorination, thereby providing a novel and more efficient process for the preparation of ledipasvir in the longest linear sequence of 8 steps with 20% overall yield.

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