Efficient Chemical and Enzymatic Syntheses of FAD Nucleobase Analogues and Their Analysis as Enzyme Cofactors**,ChemBioChem

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Efficient Chemical and Enzymatic Syntheses of FAD Nucleobase Analogues and Their Analysis as Enzyme Cofactors**
ChemBioChem ( IF 2.6 ) Pub Date : 2023-04-12 , DOI: 10.1002/cbic.202300055
Ateek Shah ₁ , Yashwant Kumar _{1,

2} , S Rohan ₁ , Amrita B Hazra ₁

Affiliation

Flavin adenine dinucleotide (FAD), the cofactor version of vitamin B₂, is essential for redox reactions in cellular metabolism. Here, we report efficient chemical and enzymatic approaches for the synthesis of FAD nucleobase analogues, their biosynthesis in cellular systems, and finally, their utilization as a catalyst for Escherichia coli glutathione reductase.

中文翻译：

FAD 核碱基类似物的高效化学和酶促合成及其作为酶辅助因子的分析**

_{黄素腺嘌呤二核苷酸 (FAD) 是维生素 B 2}的辅助因子，对于细胞代谢中的氧化还原反应至关重要。在这里，我们报告了用于合成 FAD 核碱基类似物、它们在细胞系统中的生物合成以及它们作为 大肠杆菌 谷胱甘肽还原酶催化剂的高效化学和酶促方法。

更新日期：2023-04-12

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