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Nematic Fibrin Fibers Enabling Vascularized Thrombus Implants Facilitate Scarless Cutaneous Wound Healing
Advanced Materials ( IF 27.4 ) Pub Date : 2023-04-13 , DOI: 10.1002/adma.202211149 Su Hyun Jung 1 , Bong Hwan Jang 1 , Seyong Kwon 1 , Sung Jin Park 1 , Tae-Eun Park 1 , Joo H Kang 1
Advanced Materials ( IF 27.4 ) Pub Date : 2023-04-13 , DOI: 10.1002/adma.202211149 Su Hyun Jung 1 , Bong Hwan Jang 1 , Seyong Kwon 1 , Sung Jin Park 1 , Tae-Eun Park 1 , Joo H Kang 1
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Autologous implantable scaffolds that induce vasculogenesis have shown great potential in tissue regeneration; however, previous attempts mainly relied on cell-laden hydrogel patches using fat tissues or platelet-rich plasma, which are insufficient for generating a uniform vasculature in a scalable manner. Here, implantable vascularized engineered thrombi (IVETs) are presented using autologous whole blood, which potentiate effective skin wound healing by constructing robust microcapillary vessel networks at the wound site. Microfluidic shear stresses enable the alignment of bundled fibrin fibers along the direction of the blood flow streamlines and the activation of platelets, both of which offer moderate stiffness of the microenvironment optimal for facilitating endothelial cell maturation and vascularization. Rodent dorsal skin wounds patched with IVET present superior wound closure rates (96.08 ± 1.58%), epidermis thickness, collagen deposition, hair follicle numbers, and neutrophil infiltration, which are permitted by enhanced microvascular circulation. Moreover, IVET treatment accelerates wound healing by recruiting M2 phenotype macrophages.
中文翻译：
向列型纤维蛋白纤维实现血管化血栓植入，促进无疤痕皮肤伤口愈合
诱导血管发生的自体植入支架在组织再生方面显示出巨大的潜力；然而，之前的尝试主要依赖于使用脂肪组织或富含血小板的血浆的充满细胞的水凝胶贴片，这不足以以可扩展的方式产生均匀的脉管系统。在这里，使用自体全血提出了植入式血管化工程血栓（IVET），通过在伤口部位构建强大的微毛细血管网络来增强有效的皮肤伤口愈合。微流体剪切应力使成束的纤维蛋白纤维沿着血流流线方向排列并激活血小板，这两者都提供了适度刚度的微环境，最适合促进内皮细胞成熟和血管化。用IVET修补的啮齿动物背部皮肤伤口呈现出优异的伤口闭合率（96.08±1.58%）、表皮厚度、胶原蛋白沉积、毛囊数量和中性粒细胞浸润，这是通过增强的微血管循环实现的。此外，IVET 治疗通过招募 M2 表型巨噬细胞来加速伤口愈合。
更新日期：2023-04-13
中文翻译：
向列型纤维蛋白纤维实现血管化血栓植入，促进无疤痕皮肤伤口愈合
诱导血管发生的自体植入支架在组织再生方面显示出巨大的潜力；然而，之前的尝试主要依赖于使用脂肪组织或富含血小板的血浆的充满细胞的水凝胶贴片，这不足以以可扩展的方式产生均匀的脉管系统。在这里，使用自体全血提出了植入式血管化工程血栓（IVET），通过在伤口部位构建强大的微毛细血管网络来增强有效的皮肤伤口愈合。微流体剪切应力使成束的纤维蛋白纤维沿着血流流线方向排列并激活血小板，这两者都提供了适度刚度的微环境，最适合促进内皮细胞成熟和血管化。用IVET修补的啮齿动物背部皮肤伤口呈现出优异的伤口闭合率（96.08±1.58%）、表皮厚度、胶原蛋白沉积、毛囊数量和中性粒细胞浸润，这是通过增强的微血管循环实现的。此外，IVET 治疗通过招募 M2 表型巨噬细胞来加速伤口愈合。
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