Indoles are valuable precursors in medicinal, bioorganic, and material chemistry and particularly serve as a platform for diversity. However, the scope of the C6-functionalization of indoles was limited until recently. In this short review, we summarize developments in the C6-functionalization reactions of indoles involving transition-metal-catalyzed functionalization and Brønsted and Lewis acid catalyzed processes. The regioselectivity is controlled by remote-C–H activation and hydrogen bond formation.

1 Introduction

2 Transition-Metal-Catalyzed Functionalization

3 Acid-Catalyzed Processes

4 Conclusion

中文翻译：

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吲哚的 C6–H 键功能化：一个新门

吲哚是医药、生物有机和材料化学中有价值的前体，特别是作为多样性的平台。然而，直到最近，吲哚的 C6 功能化的范围还是有限的。在这篇简短的综述中，我们总结了涉及过渡金属催化功能化和布朗斯台德和路易斯酸催化过程的吲哚 C6 功能化反应的进展。区域选择性受远程 C-H 活化和氢键形成控制。

1 简介

2 过渡金属催化的功能化

3 酸催化过程

4。结论