自愈多功能水凝胶系统通过协调免疫炎症微环境加速糖尿病伤口愈合,ACS Applied Materials & Interfaces

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自愈多功能水凝胶系统通过协调免疫炎症微环境加速糖尿病伤口愈合
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-04-12 , DOI: 10.1021/acsami.2c23323
Zhichao Hao ₁ , Gen Liu ₁ , Lin Ren ₁ , Jiangchen Liu ₁ , Chuanzi Liu ₁ , Tao Yang ₁ , Xiangnan Wu ₁ , Xinchun Zhang ₁ , Ling Yang ₁ , Juan Xia ₁ , Weichang Li ₁

Affiliation

由于多重耐药细菌感染、血管病变和伤口微环境中的氧化损伤，开发有效的药物递送治疗策略以改善糖尿病伤口愈合仍然是当今临床实践中的主要挑战。^{在此，通过具有互穿网络的自修复多动态键交联水凝胶设计了一种有效且方便的策略，该水凝胶由可逆儿茶酚-Fe 3+}的多动态键交联形成配位键、氢键和席夫碱键。席夫键引发并加速了水凝胶出色的自主愈合，席夫键在含有儿茶酚和醛基的 3,4-二羟基苯甲醛与壳聚糖链之间发生可逆断裂，并通过氢键和 Fe 贡献的其他非共价相互作用的共同选择进一步巩固³⁺协调债券。有趣的是，导管素 LL-37 被引入并均匀分散在水凝胶的动态互穿网络中，作为一种生物活性分子来协调糖尿病伤口愈合微环境。这种多功能伤口敷料可以通过抗菌活性、免疫调节、抗炎、新生血管形成和抗氧化活性显着促进糖尿病伤口愈合。因此，本研究为指导糖尿病创面处理的临床应用提供了一种有效、安全的策略。

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A Self-Healing Multifunctional Hydrogel System Accelerates Diabetic Wound Healing through Orchestrating Immunoinflammatory Microenvironment

Developing an effective treatment strategy of drug delivery to improve diabetic wound healing remains a major challenge in clinical practice nowadays, due to multidrug-resistant bacterial infections, angiopathy, and oxidative damage in the wound microenvironment. Herein, an effective and convenient strategy was designed through a self-healing multiple-dynamic-bond cross-linked hydrogel with interpenetrating networks, which was formed by multiple-dynamic-bond cross-linking of reversible catechol-Fe³⁺ coordinate bonds, hydrogen bonding, and Schiff base bonds. The excellent autonomous healing of the hydrogel was initiated and accelerated by Schiff bonds with reversible breakage between 3,4-dihydroxybenzaldehyde containing catechol and aldehyde groups and chitosan chains, and further consolidated by the co-optation of other noncovalent interactions contributed of hydrogen bonding and Fe³⁺ coordinate bonds. Intriguingly, cathelicidin LL-37 was introduced and uniformly dispersed in the dynamic interpenetrating networks of the hydrogel as a bioactive molecular to orchestrate the diabetic wound healing microenvironment. This multifunctional wound dressing can significantly promote diabetic wound healing by antibacterial activity, immunomodulation, anti-inflammation, neovascularization, and antioxidant activity. Therefore, this study provided an effective and safe strategy for guiding the diabetic wound treatment in clinical applications.

更新日期：2023-04-12

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