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Facile synthesis of 2-methyl-4-aryl-1H-pyrrole-3-carbonitriles by cathodic reduction of acetonitrile
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2016-09-24 19:14:45
Kaouthar Hamrouni, Belen Batanero, Fructuoso Barba, Taieb Saied, Mohamed Lamine Benkhoud

A new series of polyfunctionalized pyrroles has been obtained in very good yield when the product of reductive electrolysis of dry acetonitrile (3-aminocrotonitrile anion), is added to different phenacyl bromide solutions at low temperature under an argon atmosphere. The reactive anion is achieved by amperometric reduction of the solvent at stainless steel cathode and using a magnesium sacrificial anode.

中文翻译:

乙腈的阴极还原轻松合成2-甲基-4-芳基-1H-吡咯-3-腈

当在低温,氩气气氛下将干乙腈(3-氨基丁腈阴离子)的还原电解产物添加到不同的苯甲酰溴溶液中时,已经获得了一系列新的多官能吡咯,其收率很高。反应性阴离子是通过在不锈钢阴极上使用安培还原法并使用镁牺牲阳极来实现的。
更新日期:2016-09-25
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